813466-07-8

Upstream product

• 68120-56-9 1-(4-iodophenyl)ethanol 
• 813466-04-5 (+/-)-1-(4-iodophenyl)ethyl chloroacetate 
• 868054-61-9 (S)-1-(4-iodophenyl)ethyl acetate 
• 103966-63-8 (+/-)-1-(4-iodophenyl)ethyl acetate 
• 13329-40-3 4-Iodoacetophenone 
• 79-11-8 chloroacetic acid 
• 220089-24-7 (R)-(+)-1-(4-iodophenyl)ethanol 

Downstream Products

• 813466-05-6 (R)-(+)-methyl 1-[1-(4-iodophenyl)ethyl]-1H-imidazole-5-carboxylate 
• 104013-25-4 S-p-iodo-α-methylbenzyl alcohol 

Relevant academic research and scientific papers

Chemoenzymatic synthesis of stannylated metomidate as a precursor for electrophilic radiohalogenations - Regioselective alkylation of methyl 1H-imidazole-5-carboxylate [1]

Metomidate (ee 99%) substituted with iodine in the phenyl ring was prepared from (S)-1-(4-iodophenyl)ethanol (ee >98%) obtained by lipase-catalysed resolution and methyl 1H-imidazole-5-carboxylate. The two fragments were joined highly regioselectively (al

Radiolabelled phenylethyl imidazole caboxylic acid ester derivatives

Halogenated carboxylic ester derivatives of phenylethyl imidazole, and their method of preparation are disclosed. Radio-halogenated forms of these compounds are ideally suited for positron-imaging of the adrenal glands, as it is known that these compounds demonstrate a selective and high rate of accumulation in the adrenals. The method of preparing these derivatives proceeds by the conversion of a stable, non-radioactive intermediate having trialkylstannyl leaving groups. These intermediates are efficiently converted to the corresponding halogenated forms by substitution of the trialkylstannyl group with the halogen or radiohalogen.