868054-61-9

Upstream product

• 68120-56-9 1-(4-iodophenyl)ethanol 
• 13329-40-3 4-Iodoacetophenone 
• 103966-63-8 (+/-)-1-(4-iodophenyl)ethyl acetate 
• 17279-31-1 (-)-(S)-N,N-dimethyl-1-phenylethylamine 
• 108-24-7 acetic anhydride 

Downstream Products

• 813466-05-6 (R)-(+)-methyl 1-[1-(4-iodophenyl)ethyl]-1H-imidazole-5-carboxylate 
• 104013-25-4 S-p-iodo-α-methylbenzyl alcohol 
• 813466-07-8 (S)-1-(4-iodophenyl)ethyl chloroacetate 
• 220089-24-7 (R)-(+)-1-(4-iodophenyl)ethanol 

Relevant academic research and scientific papers

Chemoenzymatic synthesis of stannylated metomidate as a precursor for electrophilic radiohalogenations - Regioselective alkylation of methyl 1H-imidazole-5-carboxylate [1]

Metomidate (ee 99%) substituted with iodine in the phenyl ring was prepared from (S)-1-(4-iodophenyl)ethanol (ee >98%) obtained by lipase-catalysed resolution and methyl 1H-imidazole-5-carboxylate. The two fragments were joined highly regioselectively (al

ASYMMETRIC ACYLATION OF ALCOHOLS IN THE PRESENCE OF CHIRAL TERTIARY AMINES

The asymmetric acylation of secondary alcohols with acetic anhydride in the presence of chiral tertiary amines, synthesized from S-(-)-α-phenylethylamine, was investigated.The optical yield of the obtained alcohols was not greater than 2.4percent.It was established that in the presence of S-(-)-N,N-dimethyl-α-phenylethylamine the unreacted alcohol is rich in the S isomer.On the basis of this relationship the S configuration was proposed for (-)-4-iodo-, (-)-4-chloro-, and (-)-3-nitrophenylehanols.