81355-40-0Relevant academic research and scientific papers
SELECTIVE REDUCTION. REACTION OF 3,4-DICARBOMETHOXYQUINOLINE WITH LITHIUM ALUMINIUM HYDRIDE.
Godard, A.,Queguiner, G.
, p. 4813 - 4814 (1981)
The selective reduction of 3,4-dicarbomethoxyquinoline by lithium aluminium hydride at low temperature affords only the unexpected 3-formyl 4-carbomethoxy quinoline.The difficulty of reduction of the usually more reactive 4-ester group can be explained by a steric hindrance by the H5 peri proton on one side and by the 3-ester group on the other side.
