81364-33-2Relevant academic research and scientific papers
O-allylated pudovik and passerini adducts as versatile scaffolds for product diversification
Arseniyadis, Stellios,El Ka?m, Laurent,Kerim, Mansour Dole,Katsina, Tania,Cattoen, Martin,Fincias, Nicolas
supporting information, p. 12514 - 12525 (2020/11/10)
The palladium-catalyzed O-allylation of α-hydroxyphosphonates and α-hydroxyamides obtained from Pudovik and Passerini multicomponent reactions has allowed interesting and highly straightforward access to a variety of building blocks for product diversific
Nickel-Catalyzed Enantioconvergent Reductive Hydroalkylation of Olefins with α-Heteroatom Phosphorus or Sulfur Alkyl Electrophiles
Fu, Yao,He, Shi-Jiang,Li, Yan,Lu, Xi,Wang, Jia-Wang,Wang, Xiao-Xu,Xu, Zhe-Yuan
supporting information, (2020/01/22)
Substantial advances in enantioconvergent C(sp3)-C(sp3) bond formation reactions have been made in recent years through the use of transition-metal-catalyzed cross-coupling reactions of racemic secondary alkyl electrophiles with organometallic reagents. Herein, we report a general process for the asymmetric construction of alkyl-alkyl bonds adjacent to heteroatoms, namely, a nickel-catalyzed enantioconvergent reductive hydroalkylation of olefins with α-heteroatom phosphorus or sulfur alkyl electrophiles. Including the use of readily available olefins, this reaction has considerable advantages, such as mild reaction conditions, a broad substrate scope, and good functional group compatibility, making it a desirable alternative to traditional electrophile-nucleophile cross-coupling reactions.
Hydrophosphonylation of aldehydes catalyzed by cyclopentadienyl ruthenium(II) complexes
Cabrita, Ivania R.,Florindo, Pedro R.,Costa, Paulo J.,Oliveira, M. Concei??o,Fernandes, Ana C.
, p. 77 - 86 (2018/03/22)
This work reports the first method for the synthesis of α-hydroxyphosphonates from aldehydes catalyzed by cyclopentadienyl ruthenium(II) complexes. The best results were obtained using the system HP(O)(OEt)2/[RuClCp(PPh3)2
Palladium-catalysed O-Allylation of α-Hydroxyphosphonates: An Expedient Entry into Phosphono-oxaheterocycles
Kerim, Mansour Dolé,Cattoen, Martin,Fincias, Nicolas,Dos Santos, Aurélie,Arseniyadis, Stellios,El Ka?m, Laurent
supporting information, p. 449 - 454 (2017/12/04)
We report here an unprecedented palladium-catalysed O-allylation of α-hydroxyphosphonates. The method was eventually included in a sequential Pudovik/Tsuji-Trost type O-allylation/Ring-Closing Metathesis to afford a variety of phosphorylated heterocycles
Ultrasound assisted green synthesis of α-hydroxyphosphonates under solvent-free conditions
Bouzina, Abdeslem,Aouf, Nour-eddine,Berredjem, Malika
, p. 5993 - 6002 (2016/06/01)
Abstract: A simple, efficient and environmentally benign method for the synthesis of α-hydroxyphosphonates by reaction of an aldehyde or a ketone, and trialkylphosphite is effectively accomplished under ultrasound irradiation and solvent-free and catalyst
A simple heterogeneous catalyst for phosphite addition on carbonyl groups
Santacroce, Veronica,Paris, Emanuele,Cauzzi, Daniele,Maggi, Raimondo,Maestri, Giovanni
supporting information, p. 463 - 466 (2016/02/18)
A cheap and easily recoverable heterogeneous catalyst could efficiently trigger C-P bond formation by selective addition of phosphites to the carbonyl group of aldehydes and ketones. The reactions afford the desired products in good to excellent yields an
N-heterocyclic carbenes catalyzed phospho-aldol reaction of aldehydes
He, Lin,Cai, Zhihua,Ma, Xiaowei,Du, Guangfen
, p. 1573 - 1576 (2014/01/06)
An efficient phospho-aldol reaction of aldehydes catalyzed by N-heterocyclic carbenes (NHCs) has been developed. With 10 mol% stable NHC 1,3-bis(2,6-diisopropylphenyl)imidazol-2-ylidene, various aldehydes reacted with dialkylphosphites smoothly to provide α-hydroxy phosphonates in 59% -99% yield. In this process, NHC was assumed to function as a carbon-centered bronsted base. Copyright
Lithium perchlorate diethyl ether solution: A highly efficient media for the abramov reaction
Azizi, Najmedin,Saidi, Mohammad R.
, p. 1255 - 1259 (2007/10/03)
The α-hydroxy phosphonates are readily prepared by treating aromatic or aliphatic aldehydes and ketones with trialkylphosphite in the presence of trimethylsilylchloride in a very short time and in almost quantitative yields.
A convenient and mild procedure for the preparation of α-keto phosphonates of 1-hydroxyphosphonates under solvent-free conditions using microwave
Kaboudin,Nazari
, p. 2245 - 2250 (2007/10/03)
The Reactions of 1-hydroxyphosphonates on the alumina-supported CrO3 are accelerated by microwave irradiation under solvent-free conditions to afford a high yielding synthesis of α-keto phosphonates.
Surface-mediated solid-phase reactions: The preparation of acyl phosphonates by oxidation of 1-hydroxyphosphonates on the solid surface
Kaboudin, Babak
, p. 3169 - 3171 (2007/10/03)
Alumina-supported CrO3, under solvent-free conditions, was found to be an efficient oxidizing reagent for the preparation of acyl phosphonates from 1-hydroxyphosphonates. This method is an easy, rapid, and high-yielding reaction for the prepara
