256228-64-5Relevant articles and documents
N'-hydroxyindazolecarboximidamide derivatives, optical isomer thereof, or pharmaceutically acceptable salts thereof, and, a anticancer composition containing the same as an active ingredient
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, (2019/02/16)
A Nandprime;-hydroxyindazolecarboxyimidamide derivative compound, which is a pharmaceutical composition for anticancer medicine according to the present invention, an optical isomer thereof or a pharmaceutically acceptable salt thereof have excellent effect of inhibiting indoleamine 2,3-dioxygenase-1, and thus can be usefully used as an anticancer pharmaceutical composition.COPYRIGHT KIPO 2019
OXADIAZOLE DERIVATIVES AND PHARMACEUTICAL USES THEREOF
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Paragraph 0333-0334, (2017/02/02)
PROBLEM TO BE SOLVED: To provide therapeutic or preventive agents for various diseases or symptoms associated with a serotonin 4 receptor (particularly, neuropsychiatric diseases such as Alzheimer-type dementia). SOLUTION: The present invention provides a compound represented by formula (1) or a pharmaceutically acceptable salt thereof. In the formula (1), Het represents formula (Het-1) or the like, A represents formula (A-1) or the like, B represents (B-1) or the like, R1A represents a hydrogen atom, an alkyl group or the like, R2A, R5, R6 and R7 represent a hydrogen atom, a halogen atom, an alkyl group or the like, R8 and R9 represent a hydrogen atom, an alkyl group or the like, and l represents an integer of 0-4. SELECTED DRAWING: None COPYRIGHT: (C)2016,JPOandINPIT
Efficient synthesis of 7-substituted or 3,7-disubstituted 1H-indazoles
Cottyn, Betty,Vichard, Dominique,Terrier, Fran?ois,Nioche, Pierre,Raman
, p. 1203 - 1206 (2008/01/08)
This work reports on the synthesis of the novel indazole scaffolds 7-OTf-1H-indazole (trifluoromethanesulfonic acid 1H-indazol-7-yl ester), 7-iodo-1H-indazole and 3-bromo-7-iodo-1H-indazole. These new compounds are potent building blocks in divergent syntheses of indazoles via palladium cross-coupling reactions. Georg Thieme Verlag Stuttgart.