81390-20-7Relevant academic research and scientific papers
Efficient diastereoselective synthesis of α,β-dihydroxyesters from methyl phenylglyoxylate and aldehydes mediated by titanium trichloride/pyridine system
Clerici,Clerici,Malpezzi,Porta
, p. 13385 - 13400 (1995)
The reductive coupling of methyl phenylglyoxylate 2 with aliphatic and aromatic aldehydes 3, promoted by TiCl3/Py system in anhydrous THF, affords α,β-dihydroxyesters 4 in good yields (60-94%) and high syn-diastereoselectivity (up to 85%). The type of ligand at the metal ion necessary to achieve a high level of diastereocontrol and the possible mechanism involved are discussed.
Enantioselective equilibration-access to chiral aldol adducts of mandelic acid esters
Scholtis, Stefan,Ide, Andreas,Mahrwald, Rainer
, p. 5353 - 5355 (2007/10/03)
Syn-configured aldol products of mandelic acid esters and aldehydes were synthesized by the catalytic use of amines in the presence of titanium(IV) tert-butoxide. Used along with chiral N-methylephedrine, anti-configured α,β-dihydroxyesters were isolated
A Novel Reaction Type Promoted by Aqueous Titanium Trichloride. Synthesis of Unsymmetrical 1,2-Diols
Clerici, Angelo,Porta, Ombretta
, p. 2852 - 2856 (2007/10/02)
Electron-withdrawing substituted carbonyl compounds when allowed to react with 2 equiv of aqueous titanium trichloride in the presence of acetone, acetaldehyde, or benzaldehyde afford unsymmetrical 1,2-diols in high yields under very simple experimental conditions.
