81399-34-0

Basic information

• Product Name: 1-(4-Fluorophenyl)ethylene-2-phosphonic acid diethyl ester
• Synonyms: 1-(4-Fluorophenyl)ethylene-2-phosphonic acid diethyl ester
• CAS NO: 81399-34-0
• Molecular Weight: 258.229
• Mol File: 81399-34-0.mol
• Article Data: 8

Chemical Properties

• CAS DataBase Reference: 1-(4-Fluorophenyl)ethylene-2-phosphonic acid diethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(4-Fluorophenyl)ethylene-2-phosphonic acid diethyl ester(81399-34-0)
• EPA Substance Registry System: 1-(4-Fluorophenyl)ethylene-2-phosphonic acid diethyl ester(81399-34-0)

Safety Data

• Hazardous Substances Data: 81399-34-0(Hazardous Substances Data)

Upstream product

• 1660-94-2 Tetraethyl methylenediphosphonate 
• 459-57-4 4-fluorobenzaldehyde 
• 504433-86-7 2-[(1E)-2-(4-fluorophenyl)ethenyl]-4,4,5,5-tetramethyl-1,3,2-dioxaborolane 
• 122-52-1 triethyl phosphite 
• 706-08-1 trans-1-(4-fluorophenyl)-2-nitro-ethene 
• 762-04-9 phosphonic acid diethyl ester 
• 5153-69-5 4-fluoro-β-nitrostyrene 
• 405-99-2 para-fluorostyrene 

Downstream Products

• 107015-96-3 1-amino-2-(4-fluorophenyl)ethylphosphonic acid 
• 178878-40-5 [2-(Diethoxy-phosphoryl)-2-(4-fluoro-phenyl)-ethyl]-phosphonic acid diethyl ester 

Relevant articles and documents

Synthesis of (E)- and (Z)-alkenylphosphonates using vinylboronates

(Matrix presented) (E)- and (Z)-alkenylphosphonates have been prepared stereospecifically via the reaction of vinylboronate esters with triethyl phosphite in the presence of palladium acetate.

Cu(i)/Fe(III)-Catalyzed C-P cross-coupling of styrenes with H-phosphine oxides: A facile and selective synthesis of alkenylphosphine oxides and β-ketophosphonates

Cu(i)/Fe(iii)-Catalyzed phosphorylation and oxyphosphorylation of styrenes with H-phosphonates which can be controlled by varying the reaction temperature are developed. This study offers a new and expedient strategy for the synthesis of useful alkenylphosphine oxides and β-ketophosphonates in satisfactory yields. Moreover, the transformation is proposed to proceed via a radical process and exhibits a broad substrate scope and good functional group tolerance.

Manganese(iii)-mediated alkenyl Csp2-P bond formation from the reaction of β-nitrostyrenes with dialkyl phosphites

Mn(OAc)3-mediated tandem phosphonyl radical addition to β-nitrostyrenes followed by denitration to form (E)-2-alkenyl phosphonates in good yield is described.