504433-86-7

Usage

Uses

Used in Pharmaceutical and Agrochemical Industries:
4-Fluoro-trans-beta-styrylboro is used as a key building block for the development of pharmaceutical and agrochemical products. Its reactivity and ability to form carbon-carbon bonds facilitate the creation of complex organic molecules, contributing to the advancement of new drug and pesticide formulations.
Used in Medical Research:
4-Fluoro-trans-beta-styrylboro is utilized as a potential radiopharmaceutical and imaging agent due to the presence of the fluorine atom in its structure. This enhances its application in medical research, particularly in the development of diagnostic tools and imaging techniques for various diseases.

Upstream product

• 766-98-3 1-ethynyl-4-fluorobenzene 
• 73183-34-3 bis(pinacol)diborane 
• 76-09-5 2,3-dimethyl-2,3-butane diol 
• 1065498-68-1 4-FC₆H₄CH=CH(Bcat) 
• 1737-16-2 1-allyl-4-fluorobenzene 
• 75927-49-0 pinacol vinylboronate 
• 706-06-9 3-(4-flurophenyl)prop-2-ynoic acid 
• 405-99-2 para-fluorostyrene 
• 55718-76-8 2-chloro-1,3,2-benzodioxaborole 
• 121039-99-4 C₉H₉FO 
• 403-42-9 1-(4-fluorophenyl)ethanone 
• 25015-63-8 4,4,5,5-tetramethyl-[1,3,2]-dioxaboralane 
• 83947-56-2 4,4,5,5-tetramethyl-2-((E)-styryl)-[1,3,2]dioxaborolane 
• 100-42-5 styrene 

Downstream Products

• 1441367-65-2 {2-[(E)-2-(4-fluorostyryl)]-phenyl}-phosphonic acid diethyl ester 
• 1441367-88-9 {5-chloro-2-[(E)-2-(4-fluorophenyl)vinyl]phenyl}phosphonic acid diethyl ester 
• 1441368-13-3 {2-[(E)-2-(4-fluorophenyl)vinyl]-5-methoxyphenyl}phosphonic acid diethyl ester 
• 460748-43-0 (E)-2-(4-fluorophenyl)vinylboronic acid 
• 92356-72-4 methyl (2E,4E)-5-((p-methyl)phenyl)penta-2,4-dienoate 
• 289916-26-3 (2E,4E)-5-(4-Fluoro-phenyl)-penta-2,4-dienoic acid methyl ester 
• 410094-59-6 (E)-1-fluoro-4-(2-iodovinyl)benzene 
• 81399-34-0 1-(4-Fluorophenyl)ethylene-2-phosphonic acid diethyl ester 

Relevant academic research and scientific papers

Neosilyllithium-Catalyzed Hydroboration of Alkynes and Alkenes in the Presence of Pinacolborane (HBpin)

We report here a novel protocol for the hydroboration of alkynes and alkenes, which in the presence of neosilyllithium (LiCH2SiMe3) (5 mol %) and pinacolborane efficiently results in the formation of corresponding alkenyl and alkyl b

Reactivity of a T-shaped cobalt(i) pincer-complex

The reactivity of a paramagnetic T-shaped cobalt(i) complex, [(iPrboxmi)Co], stabilised by a monoanionic bis(oxazolinylmethylidene)-isoindolate (boxmi) NNN pincer ligand is described. The exposure to carbon monoxide as an additional neutral ligand resulted in the square-planar species [(iPrboxmi)Co(CO)], accompanied by a change in the electronic spin state from S = 1 to S = 0. In contrast, upon treatment with trimethylphosphine the formation of the distorted tetrahedral complex [(iPrboxmi)Co(PMe3)] was observed (S = 1). Reacting [(iPrboxmi)Co] with iodine (I2), organic peroxides (tBu2O2, (SiMe3)2O2) and diphenyldisulphide (Ph2S2) yielded the tetracoordinated complexes [(iPrboxmi)CoI], [(iPrboxmi)Co(OtBu)], [(iPrboxmi)Co(OSiMe3)] and [(iPrboxmi)Co(SPh)], respectively, demonstrating the capability of the boxmi-supported cobalt(i) complex to homolytically cleave bonds and thus its distinct one-electron reactivity. Furthermore, a square-planar cobalt(ii) alkynyl complex [(iPrboxmi)Co(CCArF)] was identified as the main product in the reaction between [(iPrboxmi)Co] and a terminal alkyne, 4-fluoro-1-ethynylbenzene. Putting such species in the context of the previously investigated hydroboration catalysis, its stoichiometric reaction with pinacolborane revealed its potential conversion into a cobalt(ii) hydride complex, thus confirming its original attribution as off-cycle species.

Selective hydroboration of alkynes via multisite synergistic catalysis by PCN-222(Cu)

Zirconium-based porphyrinic MOFs (PMOFs, MOF = metal-organic framework) have gained considerable attention in the field of electric/thermo/photo-catalysis as heterogeneous single-site catalysts; however, the study on multisite synergistic catalysis of PMO

Electrochemical Hydroboration of Alkynes

Herein we reported the electrochemical hydroboration of alkynes by using B2Pin2 as the boron source. This unprecedented reaction manifold was applied to a broad range of alkynes, giving the hydroboration products in good to excellent yields without the need of a metal catalyst or a hydride source. This transformation relied on the possible electrochemical oxidation of an in situ formed borate. This anodic oxidation performed in an undivided cell allowed the formation of a putative boryl radical, which reacted on the alkyne.

Cs4B4O3F10: First Fluorooxoborate with [BF4] Involving Heteroanionic Units and Extremely Low Melting Point

Herein, a new congruently melting mixed-anion compound Cs4B4O3F10 has been characterized as the first fluorooxoborate with [BF4] involving heteroanionic units. Compound Cs4B4O3F10 possesses two highly fluorinated anionic clusters and therefore its formula can be expressed as Cs3(B3O3F6) ? Cs(BF4). The influence of [BF4] units on micro-symmetry and structural evolution was discussed based on the parent compound. More importantly, Cs4B4O3F10 shows the lowest melting point among all the available borates and thus sets a new record for such system. This work is of great significance to enrich and tailor the structure of borates using perfluorinated [BF4] units.

Highly efficient hydroboration of alkynes catalyzed by porous copper-organic framework under mild conditions

The hydroboration of alkynes is crucial due to the wide applications in organic synthesis, while such reaction is often completed with low turnover frequency (TOF) value and long reaction time. Therefore, it is very important and necessary that the hydrob

Copper-Photocatalyzed Hydroboration of Alkynes and Alkenes

The photocatalytic hydroboration of alkenes and alkynes is reported. The use of newly-designed copper photocatalysts with B2Pin2 permits the formation a boryl radical, which is used for hydroboration of a large panel of alkenes and a

Creating High Regioselectivity by Electronic Metal-Support Interaction of a Single-Atomic-Site Catalyst

Ligands are the most commonly used means to control the regioselectivity of organic reactions. It is very important to develop new regioselective control methods for organic synthesis. In this study, we designed and synthesized a single-atomic-site catalyst (SAC), namely, Cu1-TiC, with strong electronic metal-support interaction (EMSI) effects by studying various reaction mechanisms. π cloud back-donation to the alkyne on the metal catalytic intermediate was enhanced during the reaction by using transient electron-rich characteristics. In this way, the reaction achieved highly linear-E-type regioselective conversion of electronically unbiased alkynes and completely avoided the formation of branched isomers (ln:br >100:1, TON up to 612, 3 times higher than previously recorded). The structural elements of the SACs were designed following the requirements of the synthesis mechanism. Every element in the catalyst played an important role in the synthesis mechanism. This demonstrated that the EMSI, which is normally thought to be responsible for the improvement in catalytic efficiency and durability in heterogeneous catalysis, now first shows exciting potential for regulating the regioselectivity in homogeneous catalysis.

Synthesis method of alkenyl borate

The invention discloses a synthesis method of alkenyl borate, which comprises the following steps: adding an alkyne substance, pinacolborane and a lithium amide catalyst into a reaction vessel filled with an organic solvent in a nitrogen atmosphere, stirring and mixing, uniformly mixing, reacting at the temperature of 70-110 DEG C for 18-28 hours, filtering and purifying after the reaction is finished to obtain a product, wherein the lithium amide catalyst is lithium bis(trimethylsilyl) amide; the alkyne substance is any one of substances such as phenylacetylene and 4-methyl phenylacetylene. The method is mild in reaction condition, easy to achieve and safe; the target product can be directly synthesized, an intermediate product does not need to be separated, and the highest yield can reach 98%; the catalyst is easy to prepare, and reactant raw materials are easy to obtain; the waste solution in the reaction process is less, other pollution gases and liquids are not discharged, so that the discharge of the waste solution is reduced, and the method has the advantages of protecting the environment and guaranteeing the health of operators.

Synthesis method of alkenyl boric acid ester

The invention discloses a synthesis method of alkenyl boric acid ester. The alkenyl boric acid ester compound with a diversified structure is obtained by catalyzing hydroboration of alkyne through rare earth. Particularly, the alkenyl boric acid ester com