81408-49-3

Usage

Uses

Used in Pharmaceutical Industry:
rac erythro-9-(2-Hydroxy-3-nonyl)adenine, Hydrochloride is used as a selective inhibitor for cGMP-stimulated phosphodiesterase (PDE2) for its ability to modulate intracellular cGMP levels, which can have therapeutic effects in treating certain diseases.
Used in Enzyme Inhibition:
In the field of biochemistry, rac erythro-9-(2-Hydroxy-3-nonyl)adenine, Hydrochloride is used as a potent inhibitor of adenosine deaminase, an enzyme involved in the breakdown of adenosine. This inhibition can be useful in studying enzyme function and developing treatments for related conditions.
Used in Research Applications:
As a chemical compound with specific inhibitory properties, rac erythro-9-(2-Hydroxy-3-nonyl)adenine, Hydrochloride is used in research settings to investigate the roles of PDE2 and adenosine deaminase in various biological processes and disease mechanisms.

Upstream product

• 78008-36-3 (R)-2,3-cyclohexylideneglyceraldehyde 
• 73-24-5 7H-purin-6-ylamine 
• 81408-41-5 Methanesulfonic acid (R)-1-((R)-1-benzyloxy-ethyl)-heptyl ester 
• 81408-40-4 (2R,3R)-2-O-benzyl-2,3-nonanediol 
• 229308-65-0 (2R,3R)-3-benzyloxy-1,2-cyclohexylidenenonane 
• 229308-69-4 (2R,3R)-3-benzyloxy-2-tetrahydropyranyloxynonane 
• 229308-58-1 (2R,3R)-1,2-cyclohexylidenenonane-1,2,3-triol 
• 229308-66-1 (2R,3R)-3-benzyloxynonane-1,2-diol 
• 229308-70-7 (2R,3R)-3-hydroxy-2-tetrahydropyranyloxynonane 
• 229308-67-2 (2R,3R)-3-benzyloxy-1-epoxynonane 
• 229308-68-3 (2R,3R)-3-benzyloxynonan-2-ol 
• 229308-71-8 9-{(S)-1-[(R)-1-(Tetrahydro-pyran-2-yloxy)-ethyl]-heptyl}-9H-purin-6-ylamine 
• 81408-48-2 (2R,3S)-3-(adenin-9-yl)-2-O-benzyl-2-nonanol 

Relevant academic research and scientific papers

Enantiospecific synthesis of some bioactive amino alcohols and related compounds from cyclohexylideneglyceraldehyde

Two bioactive amino alcohols or related derivatives, 2-aminohexadecanol I and erythro-9-(2-hydroxy-3-nonyl)adenine hydrochloride (EHNA hydrochloride) IIa, have been synthesized from some enantiomerically pure 3-alkylglycerols. The required C-3 epimeric 3-

Synthesis of Inhibitors of Adenosine Deaminase. A Total Synthesis of erythro-3-(Adenin-9-yl)-2-nonanol and Its Isomers from Chiral Precursors

The synthesis of both isomers of EHNA2 ("erythrohydroxynonyladenine") from D- and L-rhamnose is described.The key intermediates, (R)- and (S)-2-(benzyloxy)propanal, derived respectively from 5-O-benzyl-D- and -L-rhamnitol, were each condensed w