81422-30-2

Upstream product

• 108555-72-2 (11aS)(E)-2-ethylidene-2,3,5,10,11,11a-hexahydro-8-hydroxy-7-methoxy-10-methoxymethyl-5,11-dioxo-1H-pyrrolo-<2,1-c><1,4>benzodiazepine 
• 51-35-4 4R-4-hydroxyproline 
• 105342-48-1 (11aS)(Z)-2-ethylidene-2,3,5,10,11,11a-hexahydro-7-methoxy-10-methoxymethyl-8-tosyloxy-5,11-dioxo-1H-pyrrolo-<2,1-c><1,4>benzodiazepine 
• 105342-49-2 (11aS)(E)-2-ethylidene-2,3,5,10,11,11a-hexahydro-7-methoxy-10-methoxymethyl-8-tosyloxy-5,11-dioxo-1H-pyrrolo-<2,1-c><1,4>benzodiazepine 
• 89091-53-2 Benzoic acid 2-eth-(E)-ylidene-7-methoxy-11-methylsulfanyl-5-oxo-2,3,5,11a-tetrahydro-1H-benzo[e]pyrrolo[1,2-a][1,4]diazepin-8-yl ester 
• 89091-52-1 Benzoic acid 2-eth-(E)-ylidene-7-methoxy-5-oxo-11-thioxo-2,3,5,10,11,11a-hexahydro-1H-benzo[e]pyrrolo[1,2-a][1,4]diazepin-8-yl ester 
• 89091-51-0 Benzoic acid 2-eth-(E)-ylidene-7-methoxy-5,11-dioxo-2,3,5,10,11,11a-hexahydro-1H-benzo[e]pyrrolo[1,2-a][1,4]diazepin-8-yl ester 
• 35050-54-5 oxotomaymycin 
• 89091-54-3 2-Eth-(E)-ylidene-8-hydroxy-7-methoxy-11-methylsulfanyl-1,2,3,11a-tetrahydro-benzo[e]pyrrolo[1,2-a][1,4]diazepin-5-one 
• 105823-09-4 Toluene-4-sulfonic acid (2R,11aS)-7-methoxy-2-methoxymethoxy-10-methoxymethyl-5,11-dioxo-2,3,5,10,11,11a-hexahydro-1H-benzo[e]pyrrolo[1,2-a][1,4]diazepin-8-yl ester 
• 108555-62-0 (11aS)-2,3,4,5,10,11a-hexahydro-7-methoxy-10-methoxymethyl-8-tosyloxy-2,5,11-trioxo-1H-pyrrolo-<2,1-c><1,4>benzodiazepine 
• 105823-10-7 (2R,11aS)-2,3,5,10,11,11a-hexahydro-2-hydroxy-7-methoxy-10-methoxymethyl-8-tosyloxy-5,11-dioxo-1H-pyrrolo<2,1-c><1,4>benzodiazepine 
• 108555-55-1 2-iodo-N-methoxymethyl-N-(N-trifluoroacetyl-4-methoxymethoxy-1-prolyl)aniline 
• 108555-54-0 2-iodo-N-(N-trifluoroacetyl-4-methoxymethoxy-1-prolyl)aniline 

Downstream Products

• 67731-61-7 SEN-215 

Relevant academic research and scientific papers

Total Syntheses of Prothracarcin and Tomaymycin by Use of Palladium Catalyzed Carbonylation

Total syntheses of optically active prothracarcin (1) and pretomaymycin (2), which is readily convertible to tomaymycin (3), were achived via a palladium catalyzed carbonylation developed by us.The structure of prothracarcin (1) was determined to be (11aS

STRUCTURE AND SYNTHESIS OF SEN-215 AND OXOTOMAYMYCIN

The structure of SEN-215 was determined as (11aS)(E)-2-ethylidene-2,3,5,10,11,11a-hexahydro-8-hydroxy-7-methoxy-5-oxo-1H-pyrrolo(2,1-c)(1,4)benzodiazepine by conversion of (E)- and - (Z)- pretomaymycin into (E)- and (Z)- SEN-215.

A new and mild method for the reduction of secondary amides to carbinolamine ethers and imines: A conversion of oxotomaymycin to tomaymycin

A new and mild method for reducing 2° amides to carbinolamine ethers and imines and its use in the synthesis of pyrrolo[1,4]benzodiazepine antibiotics is reported.