81441-11-4

Upstream product

• 37686-68-3 2-fluoro-3,4-dimethoxybenzaldehyde 
• 394-64-9 1-fluoro-2,3-dimethoxybenzene 
• 100-44-7 benzyl chloride 
• 61338-96-3 3,4-bis(benzyloxy)-2-fluorobenzaldehyde 
• 100-39-0 benzyl bromide 

Downstream Products

• 81441-12-5 1-(3,4-Bis-benzyloxy-2-fluoro-phenyl)-2-isopropylideneamino-ethanol 
• 115562-22-6 N-[2-(3,4-Bis-benzyloxy-2-fluoro-phenyl)-2-hydroxy-ethyl]-formamide 
• 81441-16-9 2-fluoroisoproterenol oxalate 
• 115562-25-9 3-Fluoro-4-(1-hydroxy-2-methylamino-ethyl)-benzene-1,2-diol; compound with oxalic acid 
• 115562-23-7 1-(3,4-Bis-benzyloxy-2-fluoro-phenyl)-2-methylamino-ethanol 
• 81441-14-7 2-fluoronorepinephrine oxalate 

Relevant academic research and scientific papers

Syntheses and Adrenergic Activities of Ring-Fluorinated Epinephrines

The study of chemical and biological effects of fluorine substitution on the aromatic ring of catecholamines has now been extended to epinephrine (Epi). 2- and 6-fluoroepinephrines (2-FEpi and 6-FEpi) have been synthesized.Fluorine substitution on the 2- or 6-carbon of the aromatic ring alters the selectivity of epinephrine toward α- and β-adrenergic receptors, similar in manner to the change in selectivity seen with norepinephrine (NE).Thus, 2-FEpi is a relatively selective β-adrenergic ligand, while 6-FEpi is a relatively selective α-adrenergic ligand.Fluorine substitution of Epi also can markedly increase potency at either α- or β-adrenergic receptors.