61338-96-3Relevant academic research and scientific papers
Syntheses and Adrenergic Activities of Ring-Fluorinated Epinephrines
Adejare, Adeboye,Gusovsky, Fabian,Padgett, William,Creveling, Cyrus R.,Daly, John W.,Kirk, Kenneth L.
, p. 1972 - 1977 (2007/10/02)
The study of chemical and biological effects of fluorine substitution on the aromatic ring of catecholamines has now been extended to epinephrine (Epi). 2- and 6-fluoroepinephrines (2-FEpi and 6-FEpi) have been synthesized.Fluorine substitution on the 2- or 6-carbon of the aromatic ring alters the selectivity of epinephrine toward α- and β-adrenergic receptors, similar in manner to the change in selectivity seen with norepinephrine (NE).Thus, 2-FEpi is a relatively selective β-adrenergic ligand, while 6-FEpi is a relatively selective α-adrenergic ligand.Fluorine substitution of Epi also can markedly increase potency at either α- or β-adrenergic receptors.
