81452-97-3

Basic information

• Product Name: (+/-)-(1R*,6R*)-1-methyl-2-phenylcyclohexanecarboxylic acid
• Synonyms: (+/-)-(1R*,6R*)-1-methyl-2-phenylcyclohexanecarboxylic acid
• CAS NO: 81452-97-3
• Molecular Weight: 218.296
• Mol File: 81452-97-3.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: (+/-)-(1R*,6R*)-1-methyl-2-phenylcyclohexanecarboxylic acid(CAS DataBase Reference)
• NIST Chemistry Reference: (+/-)-(1R*,6R*)-1-methyl-2-phenylcyclohexanecarboxylic acid(81452-97-3)
• EPA Substance Registry System: (+/-)-(1R*,6R*)-1-methyl-2-phenylcyclohexanecarboxylic acid(81452-97-3)

Safety Data

• Hazardous Substances Data: 81452-97-3(Hazardous Substances Data)

Upstream product

• 113133-29-2 (+/-)-(3R*,4R*)-3-carbomethoxy-3-methyl-4-phenylcyclohex-1-ene 
• 16605-99-5 biphenyl-2-carboxylic acid methyl ester 
• 76660-97-4 (1R,2R)-1-Methyl-2-phenyl-cyclohexanecarbaldehyde 
• 113133-30-5 (+/-)-(1R*,6R*)-1-methyl-6-phenyl-2-cyclohexene-1-carboxylic acid 
• 1895-97-2 2-methyl-3-phenylacrylic acid 
• 93959-08-1 1α-Acetyl-1β-chlor-2α-phenyl-cyclohexan 
• 93959-09-2 1α-Methyl-2α-phenyl-cyclohexan-1β-carbonsaeuremethylester 
• 76660-97-4 (1S,2R)-1-Methyl-2-phenyl-cyclohexanecarbaldehyde 
• 107619-42-1 (+/-)-1-methyl-6t-phenyl-cyclohex-3-ene-r-carboxylic acid 
• 107620-57-5 (+/-)-1-methyl-2c-phenyl-cyclohex-3-ene-r-carboxylic acid 
• 107620-57-5 (+/-)-1-methyl-2t-phenyl-cyclohex-3-ene-r-carboxylic acid 

Downstream Products

• 113133-31-6 (1S,2S)-1-Methyl-2-phenyl-cyclohexanecarbonyl chloride 
• 76704-91-1 (+/-)-cis-1-methylcyclohexane-1,2-dicarboxylic acid 
• 13185-53-0 (+/-)-trans-1-methylcyclohexane-1,2-dicarboxylic acid 

Relevant articles and documents

Enantioselective Birch Reduction and Reductive Alkylations of Chiral 2-Phenylbenzoic Acid Derivatives. Application to the Synthesis of Hydrofluoren-9-ones, Hydrophenanthren-9-ones, and (-)-(1R,2R)-2-Phenylcyclohexanamine

Reductive alkylations of the chiral 2-phenylbenzoic acid amide 1 give 3-alkyl-4-phenylcyclohex-1-ene-3-carboxylic acid derivatives 2a-d with high diastereoselectivities.The chiral auxiliary can be removed by reaction with methyllithium to give enantiomeri

DIASTEREOSELECTIVE AND ENANTIOSELECTIVE SYNTHESIS OF 1,2-DISUBSTITUTED CYCLOALKANECARBOXALDEHYDES

A highly useful method for diastereoselective and enantioselective synthesis of trans- and cis-1,2-disubstituted cycloalkanecarboxaldehydes (trans- and cis-10), useful chiral synthons having asymmetric tertiary and quaternary carbon atoms in vicinal positions in their rings, is devised starting from cycloalkenecarboxaldehydes (5). t-Leucine t-butyl ester (2.R=But), a highly effective chiral auxiliary reagent in the present method, can be recovered for recycling without any loss of optical purity.Some mechanistic explanations on the strereochemical courses of the reactions are presented.