815600-94-3

Upstream product

• 403-43-0 4-fluorobenzoyl chloride 
• 18598-63-5 L-cysteine methyl ester hydrochloride 
• 4278-01-7 ethyl 4-(fluorophenyl)carboximidate hydrochloride 
• 459-57-4 4-fluorobenzaldehyde 
• 459-23-4 4-fluorobenzaldoxime 
• 1194-02-1 4-fluorobenzonitrile 
• 815600-95-4 2-(4-fluorophenyl)-4,5-dihydro-thiazole-4-carboxylic acid 
• 74-88-4 methyl iodide 

Downstream Products

• 1314419-46-9 methyl 2-(4-fluorophenyl)thiazole-4-carboxylate 
• 1370731-42-2 methyl 2-(p-fluorophenyl)-5-phenylthiazole-4-carboxylate 
• 815600-95-4 2-(4-fluorophenyl)-4,5-dihydro-thiazole-4-carboxylic acid 

Relevant academic research and scientific papers

Copper-catalyzed oxidation of azolines to azoles

We report herein convenient, aerobic conditions for the oxidation of thiazolines to thiazoles and data regarding the oxidation mechanism. These reactions feature operationally simple and environmentally benign conditions and proceed in good yield to afford the corresponding azoles, thus enabling the inexpensive preparation of valuable molecular building blocks. Incorporation of a novel diimine-ligated copper catalyst, [(MesDABMe) CuII(OH2)3]2+ [-OTf] 2, provides increased reaction efficiency in many cases. In other cases copper-free conditions involving a stoichiometric quantity of base affords superior results.

Pd(ii)-catalyzed direct C5-arylation of azole-4-carboxylates through double C-H bond cleavage

The first palladium-catalyzed direct C5-arylation of azole-4-carboxylates with simple unactivated arenes through double C-H bond cleavage is realized. This protocol provided a straightforward access to diverse 5-arylsubstituted azole-4-carboxylic derivatives with good functional group tolerance. The Royal Society of Chemistry 2012.

THIAZOLINE DERIVATIVES AS SELECTIVE ANDROGEN RECEPTOR MODULATORS (SARMS)

The present invention is directed to novel thiazoline derivatives of the general fomula (I); wherein all variables are as herein defined, pharmaceutical compositions containing them and their use in the treatment of disorders and conditions modulated by t