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Usage

Uses

Used in Pharmaceutical Industry:
1-(4-Methoxy-benzyl)-1H-[1,2,3]triazole-4-carboxylic acid ethyl ester is used as a pharmaceutical agent for its potential antifungal and anticancer properties. The ethyl ester modification may improve the compound's bioavailability and efficacy, making it a promising candidate for the development of new drugs targeting fungal infections and cancer cells.
Used in Medicinal Chemistry Research:
In the field of medicinal chemistry, 1-(4-Methoxy-benzyl)-1H-[1,2,3]triazole-4-carboxylic acid ethyl ester serves as a valuable compound for research and development. Its unique structure and properties allow scientists to explore its interactions with biological targets and evaluate its potential as a lead compound for the synthesis of novel therapeutic agents.
Used in Agricultural Applications:
1-(4-Methoxy-benzyl)-1H-[1,2,3]triazole-4-carboxylic acid ethyl ester may also find use in agriculture as a potential antifungal agent. Its application could help in the development of new fungicides to protect crops from various fungal diseases, thereby contributing to increased crop yields and food security.

Upstream product

• 70978-37-9 1-(azidomethyl)-4-methoxybenzene 
• 623-47-2 propynoic acid ethyl ester 
• 105-37-3 Ethyl propionate 

Downstream Products

• 716361-79-4 1-(4-methoxybenzyl)-1H-1,2,3-triazole-4-carboxylic acid 

Relevant academic research and scientific papers

4β-amidotriazole linked podophyllotoxin congeners: DNA topoisomerase-IIα inhibition and potential anticancer agents for prostate cancer

Topoisomerases (topo-I and topo-II) have occupied a significant role in DNA replication, transcription, and are a promising set of antitumor targets. In the present approach, a series of new 4β-amidotriazole linked podophyllotoxin derivatives (10a-i and 1

N-Benzylimidazole carboxamides as potent, orally active stearoylCoA desaturase-1 inhibitors

A potent, small molecule inhibitor with a favorable pharmacokinetic profile to allow for sustained SCD inhibition in vivo was identified. Starting from a low MW acyl guanidine (5a), identified with a RapidFire High-Throughput Mass Spectrometry (RF-MS) assay, iterative library design was used to rapidly probe the amide and tail regions of the molecule. Singleton synthesis was used to probe core changes. Biological evaluation of a SCD inhibitor (5b) included in vitro potency at SCD-1 and in vivo modulation of the plasma desaturation index (DI) in rats on a low essential fatty acid (LEFA) diet. In addition to dose-dependent decrease in DI, effects on rodent ocular tissue were noted. Therefore, in rat, these SCD inhibitors only recapitulate a portion of phenotype exhibited by the SCD-1 knockout mouse.

PYRAZOLE DERIVATIVES AS CYTOCHROME P450 INHIBITORS

The present invention provides compounds of formula (I), or pharmaceutically acceptable salts or solvates thereof, methods for their preparation, methods for their use, and pharmaceutical formulations comprising them.

Dipolar Cycloaddition Reactions of Organic Azides with some Acetylenic Compounds

Phenyl azide 1 and several substituted benzyl azides 2a-o underwent 1,3-dipolar cycloaddition reactions with dimethyl acrtylenedicarboxylate 3, phenylacetylene 4 and ethyl propiolate 5 to afford the triazoles 6-13.The reactions of these azides with ethyl

Studies of v-Triazoles. Part 4. The 4-Methoxybenzyl Group, a Versatile N-Protecting Group for the Synthesis of N-Unsubstituted v-Triazoles

A series of readily prepared monocyclic N-(4-methoxybenzyl)-v-trizoles (1) have been converted into their N-unsubstituted derivatives (2) by treatment with trifluoroacetic acid at 65 deg C.The procedure allows the synthesis of a range of N-unsubstituted v