81585-29-7

Upstream product

• 2169-69-9 ethyl (E)-2-cyano-3-phenyl-2-propenoate 
• 17356-08-0 thiourea 
• 2025-40-3 ethyl benzylidenecyanoacetate 
• 81585-39-9 5-Ethoxycarbonyl-4-oxo-6-phenyl-2-thioxohexahydropyrimidine 
• 98011-28-0 6-amino-4-phenyl-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carboxamide 
• 709-79-5 (E)-2-cyano-3-phenylacrylamide 
• 98011-34-8 5-Aminocarbonyl-4-oxo-6-phenyl-2-thioxohexahydropyrimidine 
• 2700-22-3 Benzylidenemalononitrile 

Downstream Products

• 1096712-76-3 C₁₁H₈ClN₃S 
• 70638-52-7 5-cyano-6-phenyl-2-thiouracil 
• 126277-92-7 C₁₅H₁₃N₃O₃S 
• 37465-59-1 2,4-dioxo-6-phenyl-1,2,3,4-tetrahydropyrimidine-5-carbonitrile 

Relevant academic research and scientific papers

Chromium(III) chloride catalyzed one-pot synthesis of pyrtmidine-2-thiones from arylidines and thioureas

An efficient and high yielding method for two component, one-pot synthesis of pyrimidine-2-thiones from arylidines and thioureas using chromium(III) chloride as catalyst under aqueous conditions is reported.

Synthesis of some new pyrimidine and pyrimido[4,5-d]pyrimidine derivatives

A convenient synthesis of a series of pyrimidine carbonitrile, thiopyrimidine, and pyrimidopyrimidine derivatives, via the reactions of the versatile, readily accessible 6-aryl-4-oxo-2-thioxo-hexahydro-pyrimidine-5- carbonitrile with the appropriate reagents, is described. Copyright Taylor & Francis Group, LLC.

An efficient synthesis of 4-oxo-2-thioxohexahydropyrimidines

Several 4-oxo-2-thioxohexahydropyrimidines have been synthesised in very good yields from ethyl 2-cyanopropenoates and thiourea in sodium methoxide-methanol medium.

SYNTHESIS OF HETEROCYCLIC COMPOUNDS XXII. PREPARATION OF 6-ARYL-2-THIOXOPYRIMIDINES

The reactions of different ethyl benzylidenecyanoacetates (I) and benzylidenemalononitriles (V) with thiourea in an alcohol-alkoxide medium, provide a new and simple method for the synthesis of 6-aryl-5-cyano-4-oxo-2-thioxohexahydropyrimidines (III) and 4