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Usage

Uses

Used in Pharmaceutical Industry:
2-CYANO-3-PHENYLACRYLAMIDE is used as a key intermediate in the production of pharmaceuticals for its ability to be incorporated into the synthesis of diverse bioactive molecules.
Used in Organic Chemistry:
2-CYANO-3-PHENYLACRYLAMIDE serves as a starting material in organic chemistry, enabling the synthesis of a wide range of compounds due to its versatile reactivity.
Used in Antimicrobial Applications:
2-CYANO-3-PHENYLACRYLAMIDE is used as an antimicrobial agent, exhibiting properties that can potentially be harnessed for the development of new antimicrobial treatments.
Used in Anti-inflammatory Applications:
2-CYANO-3-PHENYLACRYLAMIDE is used as an anti-inflammatory agent, with its properties indicating potential use in the development of treatments for inflammatory conditions.
Used in Research and Development:
2-CYANO-3-PHENYLACRYLAMIDE is utilized in the medical and pharmaceutical industries for further research and development, given its antimicrobial and anti-inflammatory properties, as well as its potential for synthesis into new therapeutic agents.

InChI:InChI=1/C10H8N2O/c11-7-9(10(12)13)6-8-4-2-1-3-5-8/h1-6H,(H2,12,13)/b9-6+

Upstream product

• 141-52-6 sodium ethanolate 
• 100-52-7 benzaldehyde 
• 107-91-5 cyanoacetic acid amide 
• 538-51-2 benzylidene phenylamine 
• 7732-18-5 water 
• 19064-77-8 C-phenyl-N-p-tolyl-nitrone 
• 1750-36-3 (E)-N-benzylidenebenzenamine 
• 7216-46-8 2-cyano-3-phenylpropanamide 
• 72568-47-9 2-amino-3-cyano-5-ethoxycarbonyl-6-methyl-4-phenyl-4H-pyran 
• 101342-39-6 2-amino-4-phenyl-4H-pyran-3,5-dicarbonitrile 
• 81829-58-5 2-amino-5-benzoyl-4,6-diphenyl-4H-pyran-3-carbonitrile 
• 2700-22-3 Benzylidenemalononitrile 
• 100-46-9 benzylamine 
• 103-49-1 dibenzylamine 

Downstream Products

• 101889-17-2 (2-carbamoyl-2-cyano-1-phenyl-ethyl)-phosphonic acid dibutyl ester 
• 7216-46-8 2-cyano-3-phenylpropanamide 
• 35059-28-0 2-cyano-3-(10-oxo-5,10-dihydro-10λ⁵-phenophosphazin-10-yl)-3-phenyl-propionamide 
• 129650-68-6 5-amino-2-benzylidene-6-carboxamido-7-phenyl-7H-thiazolo<3,2-a>pyrimidin-3-one 
• 123858-44-6 α-cyano-2,3-dihydro-2-oxo-β-phenyl-1H-indole-3-propanamide 
• 123506-52-5 7-Amino-1,3-dimethyl-2,4-dioxo-5-phenyl-1,2,3,4-tetrahydro-pyrido[2,3-d]pyrimidine-6-carboxylic acid amide 
• 35221-08-0 1,7-Dihydro-5,7-dimethyl-3-phenyl-4H-pyrazolo<3,4-d>pyrimidin-4,6(5H)-dion 
• 1867-37-4 Benzylmalononitrile 
• 109-77-3 malononitrile 
• 36337-27-6 2-amino-4-phenyl-5,6,7,8-tetrahydronaphthalene-1,3-dicarbonitrile 
• 141811-29-2 2-amino-4-(phenyl)-5,6,7,8,9,10-hexahydrobenzo[a]cyclooctane-1,3-dicarbonitrile 
• 55525-94-5 5-amino-7-phenylindane-4,6-dicarbonitrile 
• 141811-38-3 2-amino-4-phenyl-6,7,8,9-tetrahydro-5H-benzocycloheptene-1,3-dicarbonitrile 
• 129115-55-5 4-phenyl-2-oxo-3-(1-pyridino)-5-cyano-3,4-trans-1,2,3,4-tetrahydro-6-pyridinolate 

Relevant academic research and scientific papers

Controlled synthesis of Fe3O4/ZIF-8 nanoparticles for magnetically separable nanocatalysts

Fe3O4/ZIF-8 nanoparticles were synthesized through a room-temperature reaction between 2-methylimidazolate and zinc nitrate in the presence of Fe3O4 nanocrystals. The particle size, surface charge, and magnetic

Bismuth (III) Triflate: A Mild, Efficient Promoter for the Synthesis of Trisubstituted Alkenes through Knoevenagel Condensation

In this work, smooth efficient and eco-friendly two component coupling method is reported for the synthesis of Knoevenagel Condensation product in presence of Bi(OTf)3 catalyst under solvent free condition. Catalyst has participated in condensation between substituted aldehydes (aromatic and hetero-aromatic) and active methylene compounds (ethyl cyanoacetate, malononitrile and cyanoacetamide) effectively to generate an excellent yield of the product. Bi(OTf)3 catalyst is stable, inexpensive and easily available was used for four times in this reaction without loss of catalytic activity. [Formula Presented]

Chitosan as a biodegradable heterogeneous catalyst for Knoevenagel condensation between benzaldehydes and cyanoacetamide

A natural biopolymer chitosan is being employed as heterogeneous solid base catalyst for the Knoevenagel condensation reaction between benzaldehydes and cyanoacetamide under mild reaction conditions. This reaction offers the direct synthesis of condensati

Novel synthesis of 3-cyano-2-pyridones derivatives catalyzed by Au–Co/TiO2

Abstract: The current work described a new and highly selective method for the synthesis of substituted 3-cyano-2-pyridones scaffolds using gold-cobalt supported on TiO2 as a robust and recyclable catalyst. The products were successfully obtained by one-pot, multicomponent manner. This procedure generated the desired products 2-pyridones derivatives in good yields, from simple and available starting materials using heterogeneous and reusable catalyst. The diversity of 3-cyano-2-pyridones derivatives was prepared and characterized by IR, 1H and 13C NMR data and confirmed by element analysis data. Graphic abstract: [Figure not available: see fulltext.].

Oxidative Olefination of Benzylamine with an Active Methylene Compound Mediated by Hypervalent Iodine (III)

Hypervalent iodine-mediated oxidative olefination of amines with an active methylene compound provides a rapid gateway towards the formation of electrophilic alkenes under mild reaction conditions in good to excellent yields. This is an efficient protocol for the preparation of substituted electrophilic alkenes.

Synthesis of 2-cyanoacrylamides through Pd-catalyzed monohydration of methylenemalononitriles

A straightforward and efficient method has been developed for the synthesis of 2-cyanoacrylamide from 2-methylenemalononitriles through monohydration. A series of methylenemalononitriles underwent the reaction under mild and simple reaction conditions wit

Montmorillonite-KSF mediated one step synthesis of pyranochromene derivatives

One-pot three-component reaction of substituted aromatic aldehydes, 2-cyanoacetamide and 4-hydroxycoumarin in the presence of Montmorillonite-KSF (MKSF) in ethanol results in the formation of pyrano[3,2-c]chromene-3-carboxylates (5a-m) has been described. The reaction was tested in different alcohols, afforded pyrano [3,2-c] chromene-3-carboxylates (5a-m) of the corresponding alcohols in good yield. The mechanism reveals that the alcohol (as solvent) plays a major role in the inter conversion of amide to the corresponding esters with Montmorillonite KSF (M-KSF) as a catalyst. Excellent yields, inexpensive and readily available substrates, environmentally benign reaction condition, shorter reaction time, and easy workup are the major advantageous features of this protocol.

Triflic acid-catalyzed metal-free synthesis of (: E)-2-cyanoacrylamides and 3-substituted azetidine-2,4-diones

A TfOH-catalyzed highly efficient synthesis of biologically active (E)-2-cyanoacrylamides and 3-substituted azetidine-2,4-diones has been reported with 64-94% yields under metal-free conditions. The reaction proceeds through sequential Knoevenagel condens

Knoevenagel condensation catalyzed by novel Nmm-based ionic liquids in water

A series of novel N-methyl morpholine (Nmm) based ionic liquids with 1,2-propanediol group were synthesized and used as catalysts for Knoevenagel condensation at room temperature in water. Under the effect of the catalyst, various aldehydes or aliphatic ketones could react with a wide range of activated methylene compounds well, including malononitrile, alkyl cyanoacetate, cyanoacetamide, β-diketone, barbituric acid, 2-arylacetonitrile and thiazolidinedione. Furthermore, most of the products could be separated just by filtrating and washing with water. Additionally, the catalyst is recyclable and applicable for the large-scale synthesis.

Green synthesis of a nano salt and its application as multifunctional organocatalyst for Knoevenagel condensation

1,2-Ethanediammonium 3-hydroxypropane-1-sulfonate [(EDA)(HPS)] as a novel nano multifunctional organosalt was synthesized via a simple and green chemical route and characterized using various techniques such as proton nuclear magnetic resonance (1/s