126277-92-7Relevant academic research and scientific papers
Synthesis of some new pyrimidine and pyrimido[4,5-d]pyrimidine derivatives
Fadda, Ahmed A.,El-Latif, Ehab Abd,Bondock, Samir,Samir, Ahmed
experimental part, p. 4352 - 4368 (2009/04/11)
A convenient synthesis of a series of pyrimidine carbonitrile, thiopyrimidine, and pyrimidopyrimidine derivatives, via the reactions of the versatile, readily accessible 6-aryl-4-oxo-2-thioxo-hexahydro-pyrimidine-5- carbonitrile with the appropriate reagents, is described. Copyright Taylor & Francis Group, LLC.
Glycosylation of 2-thiouracil derivatives. A synthetic approach to 3- glycosyl-2,4-dioxypyrimidines
Khodair,Ibrahim,El Ashry
, p. 433 - 444 (2007/10/03)
Reaction of 6-aryl-5-cyano-2-thiouracils 2a-d with glycosyl halides 4a,b under alkaline conditions gave the respective bisglycosylated derivatives 5a- h. However, their deacetylation with ammonia in methanol caused a cleavage of the S-glycosyl residue and gave the N-3 glycosylated analogues 6a-h.
NEW PYRIDINE DERIVATIVES: SYNTHESIS AND APPLICATION OF THIAZOLO-TRIAZOLO-PYRIMIDINE AS BACTERICIDES, FUNGICIDES AND BIOREGULATORS
Khalil, Zarif Hallem,Hafez, Ali Ahmed Abdel,Ahmed, Ahmed Abdo
, p. 81 - 94 (2007/10/02)
5-Cyano-4-oxo-6-phenyl-2-thioxo-1,2,3,4-tetrahydro pyrimidine (I) reacts with alkyl or alkaryl halides to give the corresponding 2-alkyl (alkaryl) derivatives (IIa-g); and with chloroacetic acid ethyl chloroacetate to give compounds III and IV respectively further reaction of IV with ammonia and amines yielded 5-cyano-2(glycolamidethio)-6-phenyl pyrimidine-4(3H) one derivatives (Va-g).The parent thiazolopyrimidine (VI) was prepared from compound III by refluxing with acetic anhydride.Also compound I reacted with hydrazine hydrate to give 2-hydrazino derivative IX was converted into a variety of triazolo pyrimidine derivatives.The biological activity of the new compounds was tested as microbicidal and bioregulator agents, the results obtained were correlated with their structure.Key words: Pyrimidinethione; thiazolopyrimidine; triazolopyrimidine; synthesis and reactions; biological activity.
