81585-31-1

Upstream product

• 2017-87-0 ethyl (2E)-2-cyano-3-(4-methoxyphenyl)acrylate 
• 17356-08-0 thiourea 
• 27888-23-9 (E)-3-p-anisyl-2-cyano-2-propenoyl chloride 
• 154198-90-0 (E)-3-p-anisyl-2-cyano-2-propenoyl azide 
• 50897-91-1 ethyl 2-cyano-3-(4-methoxyphenyl)-acrylate 
• 2826-26-8 2-(4-methoxyphenylmethylene)malononitrile 
• 2286-29-5 ethyl 2-cyano-3-(4-methoxyphenyl)prop-2-enoate 

Downstream Products

• 1096712-77-4 C₁₂H₁₀ClN₃OS 
• 138608-97-6 C₁₆H₁₅N₃O₄S 
• 70638-54-9 5-cyano-4-oxo-6-(4-methoxyphenyl)-2-thioxo-1,2,3,4-tetrahydropyrimidine 

Relevant academic research and scientific papers

Synthesis of some new pyrimidine and pyrimido[4,5-d]pyrimidine derivatives

A convenient synthesis of a series of pyrimidine carbonitrile, thiopyrimidine, and pyrimidopyrimidine derivatives, via the reactions of the versatile, readily accessible 6-aryl-4-oxo-2-thioxo-hexahydro-pyrimidine-5- carbonitrile with the appropriate reagents, is described. Copyright Taylor & Francis Group, LLC.

Synthesis and antimicrobial activity of thioxopyrimidines and related derivatives

The interaction of thiourea with activated cyanoolefins under different reaction conditions were studied, in which a variety of thiopyrimidines (8, 9, 12, 18, 20, & 21) and related derivatives (10, 11, 14, 16, & 17) were obtained respectively. Also, the r

An efficient synthesis of 4-oxo-2-thioxohexahydropyrimidines

Several 4-oxo-2-thioxohexahydropyrimidines have been synthesised in very good yields from ethyl 2-cyanopropenoates and thiourea in sodium methoxide-methanol medium.

Synthesis and insecticidal activity of novel acrylonitrile derivatives

(E)-3-p-Anisyl-2-cyano-2-propenoyl chloride and/or azide (1b and c) underwent successful nucleophilic displacement reactions, with urea and thiourea derivatives to give the mono-or di-displacement products (4, 8, 2 and 5) respectively, beside other cyclic

SYNTHESIS OF HETEROCYCLIC COMPOUNDS XXII. PREPARATION OF 6-ARYL-2-THIOXOPYRIMIDINES

The reactions of different ethyl benzylidenecyanoacetates (I) and benzylidenemalononitriles (V) with thiourea in an alcohol-alkoxide medium, provide a new and simple method for the synthesis of 6-aryl-5-cyano-4-oxo-2-thioxohexahydropyrimidines (III) and 4