81593-58-0Relevant academic research and scientific papers
Structure-Affinity Relationships of 2,3,4,5-Tetrahydro-1 H-3-benzazepine and 6,7,8,9-Tetrahydro-5 H-benzo[7]annulen-7-amine Analogues and the Discovery of a Radiofluorinated 2,3,4,5-Tetrahydro-1 H-3-benzazepine Congener for Imaging GluN2B Subunit-Containi
Ahmed, Hazem,Haider, Ahmed,Varisco, Jasmine,Stankovi?, Maja,Wallimann, Rahel,Gruber, Stefan,Iten, Irina,H?ne, Surya,Müller Herde, Adrienne,Keller, Claudia,Schibli, Roger,Schepmann, Dirk,Mu, Linjing,Wünsch, Bernhard,Ametamey, Simon M.
, p. 9450 - 9470 (2019/11/11)
Aspiring to develop a positron emission tomography (PET) imaging agent for the GluN2B subunits of the N-methyl-d-aspartate receptor (NMDAR), a key therapeutic target for drug development toward several neurological disorders, we synthesized a series of 2,
Design, synthesis, and biological evaluation of 3-benzazepin-1-ols as NR2B-selective NMDA receptor antagonists
Tewes, Bastian,Frehland, Bastian,Schepmann, Dirk,Schmidtke, Kai-Uwe,Winckler, Thomas,Wuensch, Bernhard
experimental part, p. 687 - 695 (2010/12/29)
Cleavage and reconstitution of a bond in the piperidine ring of ifenprodil (1) leads to 7-methoxy-2,3,4,5-tetrahydro-1H-3-benzazepin-1-ols, a novel class of NR2B-selective NMDA receptor antagonists. The secondary amine 7-methoxy-2,3,4,5-tetrahydro-1H-3-be
