81616-75-3

Upstream product

• 579-74-8 2-Methoxyacetophenone 
• 81616-76-4 2-(2-methoxyphenyl)propenoic acid ethyl ester 
• 6056-23-1 ethyl (2-methoxyphenyl)acetate 
• 93-25-4 2-methoxyphenylacetic acid 
• 27798-60-3 methyl 2-(2-methoxyphenyl)acetate 
• 54493-88-8 methyl 2-(2-methoxyphenyl)prop-2-enoate 
• 124-38-9 carbon dioxide 
• 767-91-9 1-ethynyl-2-methoxybenzene 

Downstream Products

• 349552-88-1 2-(2-methoxyphenyl)propen-2-oyl chloride 
• 26767-06-6 2-(2-methoxyphenyl)-2-oxoacetic acid 
• 133032-95-8 α-[[(2-amino phenyl)-thio]-methyl]-2-methoxy-benzeneacetic acid 
• 1346946-62-0 3-(2-(2-methoxyphenyl)acryloyl)oxazolidin-2-one 
• 81616-80-0 (S)-2-(2-methoxyphenyl)-propionic acid 
• 96687-73-9 Methyl (S)-(+)-2-(2-methoxyphenyl)propanoate 
• 143392-21-6 3-(2-methoxyphenyl)furan-2(5H)-one 
• 1346947-73-6 C₂₁H₂₃NO₅S 
• 1346947-71-4 C₂₃H₂₁NO₄S 
• 1346947-69-0 C₁₉H₁₉NO₄S 
• 81616-80-0 (S)-2(2-methoxyphenyl)propionic acid 

Relevant academic research and scientific papers

Rh-Catalyzed Coupling of Acrylic/Benzoic Acids with α-Diazocarbonyl Compounds: An Alternative Route for α-Pyrones and Isocoumarins

A coupling of acrylic acids/benzoic acids with α-diazocarbonyl compounds has been realized by a combined catalytic system of rhodium catalyst and Zn(OAc)2 additive. The presence of Zn(OAc)2 obviously accelerates the C(sp2)

MAXI-K POTASSIUM CHANNEL OPENERS FOR THE TREATMENT OF FRAGILE X ASSOCIATED DISORDERS

The present invention relates to the compounds of formula (I) and pharmaceutical compositions containing these compounds. The compounds provided herein can act as maxi-K potassium channel openers, which makes them suitable for use in therapy, particularly in the treatment or prevention of fragile X associated disorders, such as fragile X syndrome.

Cobalt-Catalyzed Vinylic C-H Addition to Formaldehyde: Synthesis of Butenolides from Acrylic Acids and HCHO

A carboxyl-assisted C-H functionalization of acrylic acids with formaldehyde to give butenolides is described. It is the first time that the addition of an inert vinylic C-H bond to formaldehyde has been achieved via cobalt-catalyzed C-H activation. The unique reactivity of the cobalt species was observed when compared with related Rh or Ir catalysts. γ-Hydroxymethylated butenolides were produced by the treatment of Na2CO3 after the catalytic reaction in one pot.

Palladium-Catalyzed Highly Regioselective Hydrocarboxylation of Alkynes with Carbon Dioxide

A Pd-catalyzed highly regioselective hydrocarboxylation of alkynes with carbon dioxide has been established. By the combination of Pd(PPh3)4 and 2,2′-bis(diphenylphosphino)-1,1′-binaphthalene (binap), a variety of functionalized alkynes, including aryl alkynes, aliphatic alkynes, propargylamines, and propargyl ethers, could be leveraged to provide a wide array of α-acrylic acids in high yields with high regioselectivity under mild reaction conditions. Experimental and DFT mechanistic studies revealed that this reaction proceeded via the cyclopalladation process of alkynes and carbon dioxide in the presence of binap to generate a five-membered palladalactone intermediate and enabled the formation of Markovnikov adducts. Moreover, this strategy provided an effective method for the late-stage functionalization of alkyne-containing complicated molecules, including natural products and pharmaceuticals.

Macrolide Synthesis through Intramolecular Oxidative Cross-Coupling of Alkenes

A RhIII-catalyzed intramolecular oxidative cross-coupling between double bonds for the synthesis of macrolides is described. Under the optimized reaction conditions, macrocycles containing a diene moiety can be formed in reasonable yields and with excellent chemo- and stereoselectivity. This method provides an efficient approach to synthesize macrocyclic compounds containing a 1,3-conjugated diene structure.

Asymmetric Hydrogenation of α-Substituted Acrylic Acids Catalyzed by a Ruthenocenyl Phosphino-oxazoline-Ruthenium Complex

Asymmetric hydrogenation of various α-substituted acrylic acids was carried out using RuPHOX-Ru as a chiral catalyst under 5 bar H2, affording the corresponding chiral α-substituted propanic acids in up to 99% yield and 99.9% ee. The reaction could be performed on a gram-scale with a relatively low catalyst loading (up to 5000 S/C), and the resulting product (97%, 99.3% ee) can be used as a key intermediate to construct bioactive chiral molecules. The asymmetric protocol was successfully applied to an asymmetric synthesis of dihydroartemisinic acid, a key intermediate required for the industrial synthesis of the antimalarial drug artemisinin.

Enantioselective enolate protonation in sulfamichael addition to r-substituted n-acryloyloxazolidin-2-ones with bifunctional organocatalyst

Organocatalytic conjugate addition of thiols to R-substituted N-acryloyloxazolidin-2-ones followed by asymmetric protonation has been studied in the presence of cinchona alkaloid derived thioureas. Both of the enantiomers are accessible with the same level of enantioselectivity using pseudoenantiomeric quinine/quinidine derived catalysts. The addition/protonation products have been converted to useful biologically active molecules. 2011 American Chemical Society.

Process for preparing benzoperhydroisoindole compounds

The present invention relates to a novel process for the preparation of benzoperhydroisindole compounds.

Farnesyl transferase inhibitors, their preparation, the pharmaceutical compositions which contain them and their use in the preparation of medicaments

Novel products of formula (I), their preparation, the pharmaceutical compositions which contain them and their use in the preparation of medicaments. In the formula (I), the following substituents are among the preferred: Ar represents a substituted or co

4,9-ETHANO-BENZO(F)ISOINDOLE DERIVATIVES AS FARNESYL TRANSFERASE INHIBITORS

Novel products of formula (I): STR1 preparation thereof and pharmaceutical compositions containing said products are disclosed. In formula (I), R is a group of formula (CH 2) m X 1 (CH 2) n Z, where X 1 is a simple bond or O or S, n is 0 or 1 and n is 0,