81645-83-2

Upstream product

• 86-93-1 1-phenyl-1H-tetrazole-5-thiol 
• 100-11-8 1-bromomethyl-4-nitro-benzene 
• 107-06-2 1,2-dichloro-ethane 
• 86-93-1 1-Phenyl-1H-tetrazole-5-thiol 
• 81-07-2 saccharin 
• 81589-05-1 1-phenyl-5-trimethylsilylthio-1H-tetrazole 
• 100-14-1 4-nitrobenzyl chloride 

Relevant academic research and scientific papers

Direct Synthesis of Thioethers from Carboxylates and Thiols Catalyzed by FeCl3

A new and efficient method has been developed for the synthesis of thioethers from carboxylates and thiols. The reaction proceeds via a Fe(III)-catalyzed direct displacement of carboxylates from benzylic or allylic esters by heterocyclic thiols. Short rea

Cytostatic tetrazole-butenolide conjugates: Linking tetrazole and butenolide rings via stille coupling and biological activity of the target substances

A series of tetrazoles linked to the butenolide core via benzene rings were prepared by the Stille coupling reaction of α-(tributylstannyl) butenolides and 5-(alkylsulfanyl)-1-(4-iodophenyl)tetrazoles, and the compounds were tested for antifungal and cytostatic activity. Interesting antifungal activities against the filamentous strain Absidia corymbifera, and cytostatic activities against leukemic cells HL-60 and CCRF-CEM were found. The cytostatic activity requires the presence of both the butenolide ring and the alkylsulfanyl group bound to tetrazole ring. In addition, the feasibility of Pd-coupling reactions with 5-iodotetrazoles was evaluated.

Tetrazoles. XXXI. Phase-Transfer Reactions of 1-Substituted Tetrazole-5-thiones and Their Derivatives

Alkylation of 1-substituted tetrazole-5-thiones under conditions of phase-transfer catalysis in the two-phase system liquid-liquid proceeds regioselectively at the sulfur atom, regardless of the alkylating agent and phase-transfer catalyst. Phase-transfer oxidation of the 5-alkylthiotetrazoles thus obtained by potassium permanganate is a convenient method for preparation of 5-alkylsulfonyltetrazoles which can be used to synthesize functionally substituted tetrazoles.

Tetrazoles. XXXII. Reactions of 1-R-Tetrazole-5-Thiones and Their Derivatives under Conditions of Phase Transfer Catalysis. Selection of Phase Transfer Catalyst

Among the six investigated catalysts of phase transfer the most effective at alkylation of 1-phenyltetrazole-5-thione and oxidation of 5-methylthio-phenyltetrazole turned out to be the benzyldimetyhyl(5-methoxycarbonylpentyl)ammonium bromide. The directio

Phenylmercaptotetrazolo- and nitroindazolo masked development/image modifiers

Novel nitrobenzyl compounds are incorporated into a photographic emulsion or developer for controlled release of development/image modifier compounds. This occurs imagewise only after developer oxidation products have been formed in the course of the development process. For example, nitrobenzyl-masked phenylmercaptotetrazole (PMT), incorporated into a silver halide emulsion, reacts with developer oxidation products via an electron transfer mechanism to release the potent development restrainer PMT.

Preparation of thioethers

A novel process for the preparation of thioethers comprising reacting a silylated thiol of the formula wherein R is an organic group and R1, R2 and R3 are individually selected from the group consisting of alkyl of 1 to 4 carbon atoms with an organic halide, sulfate or sulfonate in the presence of hexamethylphosphoric triamide as a solvent or co-solvent preferably under neutral conditions in aprotic solvents at a temperature between 0° and 150° C.