816468-48-1 Usage
Chemical class
Pyrrolidine compounds
Explanation
1-BOC-3-(4-trifluoromethyl-phenylamino)-pyrrolidine belongs to the class of pyrrolidine compounds, which are heterocyclic organic compounds with a nitrogen atom in the ring.
Explanation
The compound is a derivative of pyrrolidine, meaning it is structurally similar to pyrrolidine but has additional functional groups attached to it.
Explanation
The compound has a tert-butoxycarbonyl (BOC) protecting group attached to the nitrogen atom, which serves to protect the nitrogen from unwanted reactions during synthesis.
Explanation
The presence of a 4-trifluoromethyl-phenylamino group in the compound contributes to its unique chemical and physical properties, such as increased electronegativity and lipophilicity.
Explanation
Due to its interesting structural features and reactivity, 1-BOC-3-(4-trifluoromethyl-phenylamino)-pyrrolidine can be used as a building block in the synthesis of various pharmaceuticals and agrochemicals.
Explanation
The compound may also be used in medicinal chemistry, as it can be incorporated into the structure of drugs to improve their efficacy, selectivity, or pharmacokinetic properties.
Explanation
1-BOC-3-(4-trifluoromethyl-phenylamino)-pyrrolidine can be used as a ligand in asymmetric catalysis, which is a type of chemical reaction that produces chiral products with high selectivity for one enantiomer over the other. This is important in the synthesis of chiral drugs and other biologically active compounds.
Explanation
The compound may also be employed in other chemical transformations, such as acting as a catalyst or a reactant in various synthetic routes, due to its unique structural features and reactivity.
Check Digit Verification of cas no
The CAS Registry Mumber 816468-48-1 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 8,1,6,4,6 and 8 respectively; the second part has 2 digits, 4 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 816468-48:
(8*8)+(7*1)+(6*6)+(5*4)+(4*6)+(3*8)+(2*4)+(1*8)=191
191 % 10 = 1
So 816468-48-1 is a valid CAS Registry Number.
816468-48-1Relevant academic research and scientific papers
Palladium-mediated arylation of 3-aminopiperidines and 3-aminopyrrolidines
Jean, Ludovic,Rouden, Jacques,Maddaluno, Jacques,Lasne, Marie-Claire
, p. 8893 - 8902 (2007/10/03)
This paper describes the palladium-catalyzed arylation of 1-substituted 3-aminopyrrolidines or piperidines. Palladium(0) (1-2 mol %) in conjunction with "Buchwald's ligand" [2-(dimethylamino)-2′- (dicyclohexylphosphine)biphenyll was shown to be the catalyst of choice for the coupling with aryl bromides or chlorides. When bromobenzene was used, a strong temperature effect was noticed. Whereas no reaction occurred at 100 °C, yields higher than 85% were obtained at 130 °C for each substrate. Such an effect was not observed when diphosphines were used. Whereas Xantphos and, to a lesser extent BINAP, were moderately efficient in the coupling of all diamines, the palladium-mediated arylation in the presence of monophosphines was strongly dependent on the substrate. The results suggest the participation of both nitrogens of the aminoheterocycle in the reactive intermediate. This participation could also account for the highly selective arylation of the endocyclic nitrogen of unsubstituted 3-aminopyrrolidine or piperidine. Optimal conditions were found for the arylation using 2- or 4-substituted electron-poor or enriched aryl halides.
