α,α-bis(trifluoromethyl)-4,5-bis(4-fluorophenyl)-1-methyl-1H-imidazole-2-methanamine

Base Information

• Chemical Name: α,α-bis(trifluoromethyl)-4,5-bis(4-fluorophenyl)-1-methyl-1H-imidazole-2-methanamine
• CAS No.: 81659-38-3
• Molecular Formula: C₁₉H₁₃F₈N₃
• Molecular Weight: 435.32
• Mol file: 81659-38-3.mol

Synonyms:α,α-bis(trifluoromethyl)-4,5-bis(4-fluorophenyl)-1-methyl-1H-imidazole-2-methanamine

Chemical Property of α,α-bis(trifluoromethyl)-4,5-bis(4-fluorophenyl)-1-methyl-1H-imidazole-2-methanamine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of α,α-bis(trifluoromethyl)-4,5-bis(4-fluorophenyl)-1-methyl-1H-imidazole-2-methanamine

There total 2 articles about α,α-bis(trifluoromethyl)-4,5-bis(4-fluorophenyl)-1-methyl-1H-imidazole-2-methanamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

[1,1-di(trifluoromethyl)methyleneamino]-trimethylsilane (17599-55-2) + 4,5-Bis-(4-fluoro-phenyl)-1-methyl-1H-imidazole (178553-80-5) → α,α-bis(trifluoromethyl)-4,5-bis(4-fluorophenyl)-1-methyl-1H-imidazole-2-methanamine (81659-38-3)

Guidance literature:

With n-butyllithium;

DOI:10.3987/COM-96-7418

Reference yield:

4,5-bis(4-fluorophenyl)-1H-imidazole (68163-71-3) → α,α-bis(trifluoromethyl)-4,5-bis(4-fluorophenyl)-1-methyl-1H-imidazole-2-methanamine (81659-38-3)

Guidance literature:

Multi-step reaction with 2 steps

1: 80 percent / NaH

2: 69 percent / 1.) n-BuLi

With n-butyllithium; sodium hydride;

DOI:10.3987/COM-96-7418

Reference yield: 72.0%

α,α-bis(trifluoromethyl)-4,5-bis(4-fluorophenyl)-1-methyl-1H-imidazole-2-methanamine (81659-38-3) → 4-Fluoro-N-[2-(4-fluoro-phenyl)-3-methyl-5,5-bis-trifluoromethyl-3,5-dihydro-imidazol-(4Z)-ylidene]-benzamide

Guidance literature:

With 3-chloro-benzenecarboperoxoic acid; In chloroform; Heating;

DOI:10.1016/0960-894X(96)00137-0

upstream raw materials:

[1,1-di(trifluoromethyl)methyleneamino]-trimethylsilane

4,5-Bis-(4-fluoro-phenyl)-1-methyl-1H-imidazole

4,5-bis(4-fluorophenyl)-1H-imidazole

Downstream raw materials:

[2-(4-Fluoro-phenyl)-3-methyl-5,5-bis-trifluoromethyl-4,5-dihydro-3H-imidazol-4-yl]-methyl-amine

4-Fluoro-N-[2-(4-fluoro-phenyl)-3-methyl-5,5-bis-trifluoromethyl-4,5-dihydro-3H-imidazol-4-yl]-benzamide

4-Fluoro-N-[2-(4-fluoro-phenyl)-3-methyl-5,5-bis-trifluoromethyl-4,5-dihydro-3H-imidazol-4-yl]-N-methyl-benzamide

4-Cyano-N-[2-(4-cyano-phenyl)-3-methyl-5,5-bis-trifluoromethyl-4,5-dihydro-3H-imidazol-4-yl]-N-methyl-benzamide