81674-79-5

Basic information

• Product Name: Guaimesal
• Synonyms: Guaimesal;9-(2-methoxyphenoxy)-9-methyl-8,10-dioxabicyclo[4.4.0]deca-1,3,5-trien -7-one;2-(2-Methoxyphenoxy)-2-methyl-4H-1,3-benzodioxin-4-one;2-(2-Methoxyphenoxy)-2-methyl-1,3-benzodioxan-4-one
• CAS NO: 81674-79-5
• Molecular Formula: C₁₆H₁₄O₅
• Molecular Weight: 286.28
• Mol File: 81674-79-5.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 454.7 °C at 760 mmHg
• Flash Point: 203.5 °C
• Appearance: /
• Density: 1.262 g/cm³
• Vapor Pressure: 1.86E-08mmHg at 25°C
• Refractive Index: 1.573
• CAS DataBase Reference: Guaimesal(CAS DataBase Reference)
• NIST Chemistry Reference: Guaimesal(81674-79-5)
• EPA Substance Registry System: Guaimesal(81674-79-5)

Safety Data

• Hazardous Substances Data: 81674-79-5(Hazardous Substances Data)

Usage

Uses

Guaimesal is a potential aspirin prodrug and is a degradation product of acetylsalicylic acid displaying similar effects.

InChI:InChI=1/C16H14O5/c1-16(20-14-10-6-5-9-13(14)18-2)19-12-8-4-3-7-11(12)15(17)21-16/h3-10H,1-2H3

Upstream product

• 90-05-1 2-methoxy-phenol 
• 6689-37-8 1-methoxy-2-trimethylsilyloxybenzene 
• 5538-51-2 O-acetylsalicyloyl chloride 
• 50-78-2 aspirin 

Downstream Products

• 50-78-2 aspirin 
• 90-05-1 2-methoxy-phenol 
• 69-72-7 salicylic acid 

Relevant articles and documents

Enzymatic and nonenzymatic in vitro hydrolysis of 2-methyl-2-[2-(methoxy)phenoxy]-4H-1,3-benzodioxin-4-one and 2-methoxyphenyl O-acetylsalicylate

This paper is concerned with the synthesis and physical properties as well as the enzymatic and nonenzymatic in vitro hydrolysis of the potential aspirin prodrug MR 693 (5) and the salicylic acid prodrug guacetisalum (6). The half-lives of both prodrugs and the amount of aspirin regenerated in each hydrolytic run for 5 have been estimated over a wide range of pH values.