817-09-4Relevant articles and documents
Structural Dependence of the Ising-type Magnetic Anisotropy and of the Relaxation Time in Mononuclear Trigonal Bipyramidal Co(II) Single Molecule Magnets
Shao, Feng,Cahier, Benjamin,Rivière, Eric,Guillot, Régis,Guihéry, Nathalie,Campbell, Victoria E.,Mallah, Talal
, p. 1104 - 1111 (2017)
This paper describes the correlation between Ising-type magnetic anisotropy and structure in trigonal bipyramidal Co(II) complexes. Three sulfur-containing trigonal bipyramidal Co(II) complexes were synthesized and characterized. It was shown that we can engineer the magnitude of the Ising anisotropy using ligand field theory arguments in conjunction with structural parameters. To prepare this series of compounds, we used, on the one hand, a tetradentate ligand containing three sulfur atoms and one amine (NS3tBu) and on the other hand three different axial ligands, namely, Cl-, Br-, and NCS-. The organic ligand imposes a trigonal bipyramidal arrangement with the three sulfur atoms lying in the trigonal plane with long Co-S bond distances. The magnetic properties of the compounds were measured, and ab initio calculations were used to analyze the anisotropy parameters and perform magneto-structural correlations. We demonstrate that a smaller axial zero-field splitting parameter leads to slower relaxation time when the symmetry is strictly axial, while the presence of very weak rhombicity decreases the energy barrier and speeds the relaxation of the magnetization.
A new method for synthesizing flibanserin (by machine translation)
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Paragraph 0052; 0058; 0059; 0070; 0074; 0075; 0081; 0085, (2019/02/04)
The invention relates to a new method for synthesizing of flibanserin, which belongs to the technical field of organic synthesis. The invention respectively in order to triethanolamine and between amino benzotrifluoride as the starting material, to prepare the piperazine intermediate; then to the O-phenylene diamine and the original four carbonate as raw material, the preparation of the ethoxy and imidazole intermediate; the obtained piperazine intermediate and benzimidazole intermediate undergo the substitution reaction, and hydrochloric acid deprotection to obtain the target product of flibanserin. The invention has few synthetic steps, few by-products, intermediate products and the target product yield is relatively high, intermediate product 2 - ethoxy and imidazole yield up 94.2%, the target product yield can reach 56.2%, it can be seen, the invention overcomes the substance in the prior art synthesis step is tedious, and more byproducts, target low yield of product defect. In addition, the present invention has a simple structure, high purity of product, the economic and environmental protection industrial line, has a very wide range of use and potential economic benefits. (by machine translation)
Preparation method of tris(2-aminoethyl)amine
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Paragraph 0025; 0026; 0028; 0029; 0031; 0032, (2019/04/13)
The invention discloses a preparation method of tris(2-aminoethyl)amine, and belongs to the technical field of compound preparation. According to the method, trolamine is used as starting materials; firstly, the trolamine, thionyl chloride and catalysts DMF are put into a reactor; under the heating conditions, tris(2-chloroethyl)amine hydrochloride is generated; then, the purified tris(2-chloroethyl)amine hydrochloride and ammonium hydroxide are dissolved into an organic solvent and put into the reactor; reaction is performed under the heating condition to obtain the tris(2-aminoethyl)amine hydrochloride; finally, the tris(2-aminoethyl)amine hydrochloride reacts with sodium hydroxide to obtain tris(2-aminoethyl)amine. The reaction route is short; the controllability is high.
