81731-54-6

Basic information

• Product Name: 1-((dimethylamino)methyl)cyclohexane-1-carbaldehyde
• Synonyms: 1-((dimethylamino)methyl)cyclohexane-1-carbaldehyde
• CAS NO: 81731-54-6
• Molecular Weight: 169.267
• Mol File: 81731-54-6.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 1-((dimethylamino)methyl)cyclohexane-1-carbaldehyde(CAS DataBase Reference)
• NIST Chemistry Reference: 1-((dimethylamino)methyl)cyclohexane-1-carbaldehyde(81731-54-6)
• EPA Substance Registry System: 1-((dimethylamino)methyl)cyclohexane-1-carbaldehyde(81731-54-6)

Safety Data

• Hazardous Substances Data: 81731-54-6(Hazardous Substances Data)

Upstream product

• 2043-61-0 cyclohexanecarbaldehyde 
• 51-80-9 bis-(dimethylamino)methane 
• 53282-55-6 (trimethylsiloxymethylidene)cyclohexane 
• 50-00-0 formaldehyd 
• 124-40-3 dimethyl amine 

Downstream Products

• 39943-40-3 1-(N,N-dimethylaminomethyl)-1-(hydroxymethyl)cyclohexane 
• 39943-24-3 (1-Benzhydryloxymethyl-cyclohexylmethyl)-dimethyl-amine 

Relevant articles and documents

Carbon-Carbon Bond Formation by the Use of Chloroiodomethane as a C1 Unit. III. A Convenient Synthesis of the Mannich Base from Enol Silyl Ether by a Combination of Chloroiodomethane and N,N,N',N'-Tetramethylmethanediamine

The Mannich dimethylaminomethylation of carbonyl compounds is conveniently carried out via enol trimethylsilyl ethers by a combination of chloroiodomethane (CH2ClI) and N,N,N',N'-tetramethylmethanediamine (TMMD) in DMSO as the solvent at ambient temperatute.The mechanism of the transformation is discussed on the basis of product analysis and 1H NMR spectral studies.The reagent system CH2ClI/TMMD also provides a convenient route to the Eschenmoser's salt ().