81740-18-3

Usage

Uses

Used in Pharmaceutical Industry:
1-N-BOC-3-FLUORO-ANILINE is used as an intermediate for the synthesis of active pharmaceutical ingredients, leveraging its unique structure to contribute to the development of new medications.
Used in Organic Synthesis:
As a building block in organic synthesis, 1-N-BOC-3-FLUORO-ANILINE is utilized for the creation of a variety of organic molecules, taking advantage of its fluorine atom and BOC protecting group to facilitate specific chemical reactions and molecular constructions.
Used in Medicinal Chemistry:
1-N-BOC-3-FLUORO-ANILINE is employed as a versatile reagent in medicinal chemistry, where its unique chemical properties are harnessed to advance the discovery and design of novel therapeutic agents.
Used in Agrochemicals:
In the agrochemical industry, 1-N-BOC-3-FLUORO-ANILINE is used to develop new compounds for agricultural applications, potentially enhancing crop protection and productivity through its incorporation into innovative chemical formulations.
Used in Materials Science:
1-N-BOC-3-FLUORO-ANILINE also finds use in materials science, where its properties may contribute to the development of new materials with specialized characteristics, such as improved stability or reactivity in various applications.

InChI:InChI=1/C11H14FNO2/c1-11(2,3)15-10(14)13-9-6-4-5-8(12)7-9/h4-7H,1-3H3,(H,13,14)

Upstream product

• 372-19-0 meta-fluoroaniline 
• 24424-99-5 di-tert-butyl dicarbonate 

Downstream Products

• 81740-25-2 2-Oxo-2,3-dihydro-benzooxazole-7-carboxylic acid (4-chloro-phenyl)-amide 
• 81740-24-1 7-(Hydroxy-phenyl-methyl)-3H-benzooxazol-2-one 
• 81740-26-3 7-Phenylsulfanyl-3H-benzooxazol-2-one 
• 329217-19-8 N-(tert-butoxycarbonyl)-3-fluoro-2-thiophenylaniline 
• 329217-21-2 3-fluoro-2-thiophenylaniline 
• 329217-23-4 3-fluoro-2-(thiophenyl)phenyl isocyanate 
• 1182602-58-9 tert-butyl 3-fluoro-2-(trimethylsilyl)phenylcarbamate 
• 1182602-61-4 tert-butyl 3-fluoro-2,4-bis(trimethylsilyl)phenylcarbamate 
• 1351593-82-2 6-(3,5-dimethoxy-4-propoxybenzyl)-3-ethyloxazolo[4,5-H]isoquinolin-2(3H)-one 
• 1351593-84-4 6-(3,5-dimethoxy-4-propoxybenzoyl)-3-ethyloxazolo[4,5-H]isoquinolin-2(3H)-one 
• 861931-75-1 tert-butyl N-(2-bromo-5-fluorophenyl)carbamate 
• 1057720-44-1 tert-butyl N-(2-bromo-5-fluorophenyl)-N-(prop-2-ynyl)carbamate 

Relevant academic research and scientific papers

Ligand-Promoted Meta-C-H Arylation of Anilines, Phenols, and Heterocycles

Here we report the development of a versatile 3-acetylamino-2-hydroxypyridine class of ligands that promote meta-C-H arylation of anilines, heterocyclic aromatic amines, phenols, and 2-benzyl heterocycles using norbornene as a transient mediator. More than 120 examples are presented, demonstrating this ligand scaffold enables a wide substrate and coupling partner scope. Meta-C-H arylation with heterocyclic aryl iodides as coupling partners is also realized for the first time using this ligand. The utility for this transformation for drug discovery is showcased by allowing the meta-C-H arylation of a lenalidomide derivative. The first steps toward a silver-free protocol for this reaction are also demonstrated.

Highly ortho-Selective Chlorination of Anilines Using a Secondary Ammonium Salt Organocatalyst

An organocatalytic, highly facile, efficient, and regioselective ortho-chlorination of anilines is described. A secondary ammonium chloride salt has been employed as the catalyst and the reaction can be conducted at room temperature without protection from air and moisture. In addition, the reaction is readily scalable and the catalyst can be recycled and reused. This catalytic protocol has been applied to the efficient synthesis of a highly potent c-Met kinase inhibitor. Mechanistic studies revealed that unique structural features of the secondary ammonium chloride salt are important for both the catalysis and regioselectivity of the electrophilic ortho-chlorination.

MULTIPLE D2 A(NTA)GONISTS/H3 ANTAGONISTS FOR TREATMENT OF CNS-RELATED DISORDERS

The present invention relates to compounds compound according to Formula (III); and pharmaceutically acceptable salts, hydrates and solvates thereof. These compounds have D2receptor antagonist/(partial) agonist effects and H3antagonistic effects, pharmaceutical compositions thereof, and methods of using them for application in the prophylaxis or treatment of CNS disorders.

SUBSTITUTED ISOQUINOLINES AND THEIR USE AS TUBULIN POLYMERIZATION INHIBITORS

The present invention relates generally to substituted isoquinolines and their use as tubulin polymerization inhibitors. In particular, the invention relates to substituted isoquinolines which possess useful therapeutic activity, use of these compounds in methods of therapy and the manufacture of medicaments as well as compositions containing these compounds

Comparative catalytic C-H vs. C-Si activation of arenes with Pd complexes directed by urea or amide groups

Analysis of regiocontrol in Pd-catalysed C-H activation leads to observations of aryltrimethylsilyl activation and to superior results with urea-based substrates.

SUBSTITUTED DIHYDROPYRIDINES AND METHODS OF USE

Compounds are provided that are modulators of the C5a receptor. The compounds are substituted dihydropyridines and are useful in pharmaceutical compositions, methods for the treatment of diseases and disorders involving the pathologic activtation of C5a receptors.