5215-27-0Relevant articles and documents
Metal-free hydration of ynamides: Convenient approach to amides
Huang, Hai,Tang, Luning,Xi, Yang,He, Guangke,Zhu, Hongjun
, p. 1873 - 1876 (2016/04/19)
The trifluoroacetic acid (TFA) mediated hydration of ynamides was developed, which is an efficient approach for the synthesis of N-monosubstituted amides. This convenient method is effective with a wide range of substrates under room temperature condition, and the products are obtained in high to excellent yields through an easy work-up process.
Amide bond formation via C(sp3)-H bond functionalization and CO insertion
Liu, Huizhen,Laurenczy, Gabor,Yan, Ning,Dyson, Paul J.
supporting information, p. 341 - 343 (2014/01/06)
An efficient method for the synthesis of amides via Pd-catalyzed oxidative carbonylation of C(sp3)-H bonds with CO and amines is described. The route efficiently provides substituted phenyl amides from alkanes.