81745-21-3

Usage

Uses

Used in Medicinal Chemistry:
(2-Oxo-3,4-dihydro-2H-quinolin-1-yl)-acetic acid is used as a building block for the synthesis of various pharmaceutical compounds. Its quinolin-1-yl group and acetic acid group can be utilized to create new molecules with potential therapeutic properties.
Used in Drug Development:
(2-Oxo-3,4-dihydro-2H-quinolin-1-yl)-acetic acid is used as a starting material for the development of new drugs. Its unique structure and functional groups can be modified to create novel compounds with potential biological activities.
Used in Research:
(2-Oxo-3,4-dihydro-2H-quinolin-1-yl)-acetic acid is used as a research tool to study the structure-activity relationships of quinoline-based compounds. This can help in understanding the relationship between the compound's structure and its potential biological activities.
Note: The specific properties, uses, and potential biological activities of (2-Oxo-3,4-dihydro-2H-quinolin-1-yl)-acetic acid would require further research and investigation.

Upstream product

• 553-03-7 3,4-dihydro-2(1H)-quinolone 
• 105-36-2 ethyl bromoacetate 

Relevant academic research and scientific papers

A Metallaphotoredox Method for the Expansion of Benzyl SAR on Electron-Deficient Amines

A metallaphotoredox reaction is described that allows for the efficient exploration of benzyl structure-activity relationships on electron-deficient amines. Typically, accessing a variety of benzyl groups on these substrates can be difficult due to the limited availability of the prerequisite building blocks, namely benzyl halides. However, the use of aryl bromides in this metallaphotoredox reaction allows for greater diversity in the benzyl piece. The reaction scope is discussed herein, including conditions for product scaleup using flow.

Pd-Catalyzed sequential β-C(sp3)-H arylation and intramolecular amination of δ-C(sp2)-H bonds for synthesis of quinolinones: Via an N,O-bidentate directing group

The pharmacological importance of 2-quinolinone derivatives is well known. Herein, we developed an effective protocol for the synthesis of 2-quinolinone derivatives by palladium-catalyzed sequential β-C(sp3)-H arylation and selective intramolecular C(sp2)-H/N-H amination starting with aryl iodides and carboxylic acids. A novel directing group, glycine dimethylamide, was used in the synthesis. We synthesized various quinolinone derivatives, including 5-substituted quinolinones, which are difficult to obtain using the traditional pathway. The directing group could be easily removed and could be readily transformed into other useful functional groups.

4-(Benzoimidazol-2-yl)-thiazole Compounds and Related Aza Derivatives

The invention relates to compounds of Formula (I) wherein ring A, X, (R1)n, R2, R3, R4, R4′, R5, n, and p are as described in the description; to pharmaceutically acceptable salts thereof, and to the use of such compounds as medicaments, especially as modulators of the CXCR3 receptor.

4-(BENZOIMIDAZOL-2-YL)-THIAZOLE COMPOUNDS AND RELATED AZA DERIVATIVES

The invention relates to compounds of Formula (I) wherein ring A, X, (R1)n, R2, R3, R4, R4', R5, n, and p are as described in the description; to pharmaceutically acceptable salts thereof, and to the use of such compounds as medicaments, especially as modulators of the CXCR3 receptor.