81761-29-7

Basic information

• Product Name: N-(2-cyano-phenyl)-3-oxo-butanamide
• Synonyms: N-(2-cyano-phenyl)-3-oxo-butanamide
• CAS NO: 81761-29-7
• Molecular Weight: 202.213
• Mol File: 81761-29-7.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: N-(2-cyano-phenyl)-3-oxo-butanamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-(2-cyano-phenyl)-3-oxo-butanamide(81761-29-7)
• EPA Substance Registry System: N-(2-cyano-phenyl)-3-oxo-butanamide(81761-29-7)

Safety Data

• Hazardous Substances Data: 81761-29-7(Hazardous Substances Data)

Upstream product

• 674-82-8 4-methyleneoxetan-2-one 
• 1885-29-6 anthranilic acid nitrile 
• 141-97-9 ethyl acetoacetate 

Relevant articles and documents

Environmentally benign synthesis of 4-aminoquinoline-2-ones using recyclable choline hydroxide

Greener synthesis of 4-aminoquinoline-2-ones was achieved by intramolecular cyclization of 2-cyanophenylamide derivatives using biodegradable and recyclable choline hydroxide (ChOH). The reaction proceeds rapidly and affords the corresponding 4-aminoquinoline-2-ones with a good to excellent yield. The protocol has the advantage of easy workup, high yields, and an environmentally benign methodology compared to other reported methods. The simplicity of this method makes it an interesting alternative to other approaches.

Tin (IV) chloride-promoted reactions of β-dicarbonyl compounds with nitriles. Synthesis of aminopyridines and aminoquinolines

β-Ketoesters and β-diesters react with β-enaminonitriles in the presence of stoichiometric amounts of tin (IV) chloride to give 4-aminopyridines and pyridones while they react with aromatic orthoaminonitriles to give 4-aminoquinolines and quinolones.