81784-51-2

Upstream product

• 27816-53-1 1,5-dimethyl-1H-indole 

Downstream Products

• 1592481-85-0 ((4aS,9aS)-4a,6,9-trimethyl-3-phenyl-4,4a,9,9a-tetrahydro-1H-pyridazino[3,4-b]indol-1-yl)(phenyl)methanone 
• 1431726-33-8 C₂₀H₂₂N₂O₂S 
• 1235886-07-3 C₁₉H₁₇N 

Relevant academic research and scientific papers

B(C6F5)3-Catalyzed Direct C3 Alkylation of Indoles and Oxindoles

The direct C3 alkylation of indoles and oxindoles is a challenging transformation, and only a few direct methods exist. Utilizing the underexplored ability of triaryl boranes to mediate the heterolytic cleavage of α-nitrogen C-H bonds in amines, we have developed a catalytic approach for the direct C3 alkylation of a wide range of indoles and oxindoles using amine-based alkylating agents. We also employed this borane-catalyzed strategy in an alkylation-ring opening cascade.