81806-30-6

Upstream product

• 13734-34-4 N-tert-butoxycarbonyl-L-phenylalanine 
• 1926-80-3 methyl 6-aminocaproate hydrochloride 
• 67-56-1 methanol 
• 128372-97-4 N-tert-butoxycarbonyl-6-aminohexanoic acid methyl ester 
• 6404-29-1 6-(tert-butoxycarbonylamino)hexanoic acid 

Downstream Products

• 81806-35-1 Boc-Gly-Phe-εAhx-OMe 
• 81806-37-3 6-[(S)-2-(2-Amino-acetylamino)-3-phenyl-propionylamino]-hexanoic acid methyl ester; hydrochloride 
• 138199-86-7 H-PrTyr-D-Met-Gly-Phe-εAhx-OH 
• 138199-87-8 H-iPrTyr-D-Met-Gly-Phe-εAhx-OH 
• 138199-85-6 Z-iPrTyr-D-Met-Gly-Phe-εAhx-OMe 
• 138199-84-5 Z-PrTyr-D-Met-Gly-Phe-εAhx-OMe 
• 130532-52-4 (S)-6-(2-(tert-butoxycarbonylamino)-3-phenyl-propanamido)hexanoic acid 

Relevant academic research and scientific papers

Direct Catalytic Alcoholysis of Unactivated 8-Aminoquinoline Amides

Direct catalytic alcoholysis of unactivated amides is one of the most difficult challenges in organic chemistry, and an applicable method for cleaving amides used as directing groups in regioselective functionalization reactions has not been reported. Herein, we report direct catalytic alcoholysis of 8-aminoquinoline amides, which are highly effective directing groups in regioselective functionalization reactions. The reactions proceeded with a simple combination of substrates, air-stable catalysts, and alcohols, affording the corresponding esters in good yields with broad functional group tolerance. Highly chemoselective cleavage of the 8-aminoquinoline amides in the presence of related carbonyl functionalities and preliminary mechanistic studies are also described.

3R-indole methyl-6R-aromatic amino acid modified piperazine-2, 5-dione and synthesis, activity and application thereof

The invention discloses a (3R, 6R)-3-(AA-amino-n-hexanoylamino-n-butyl)-6-(indole-3-methyl)-piperazine-2, 5-dione shown as a formula. AA is L-Phe (L-phenylalanine) residues and L-Trp (L-tryptophan) residues. Also disclosed are a preparation method of the

SYNTHESIS OF ENKEPHALIN ANALOGS. PART IV. N-ALKYLATED DERIVATIVES

Four new derivatives of enkephalin analogs: H-PrTyr-D-Met-Gly-Phe-εAhx-εAhx-OH (24).H-iPrTyr-D-Met-Gly-Phe-εAhx-εAhx-Oh (25).H-Pr-Tyr-D-Met-Gly-Phe-εAhx-OH (30) and H-iPrTyr-D-Met-Gly-Phe-εAhx-OH (31) have been synthesized and tested for agonistic, antagonistic and analgesic activity.Compound 24 showed a moderate μ agonistic potency and high selectivity.

Formyl peptide chemoattractants. Synthesis and chemotactic activity.

The tetrapeptides CHO-Met-Leu-Phe-CO-NH-(CH2)n-COOMe (n = 1-5) have been synthesized. These peptides containing an omega-amino acid residue in position 4 exhibit a very high chemotactic activity. Like the chemotactic peptide CHO-Met-Leu-Phe-OMe, these tet