Boc-Phe-εAhx-OMe

Base Information

• Chemical Name: Boc-Phe-εAhx-OMe
• CAS No.: 81806-30-6
• Molecular Formula: C₂₁H₃₂N₂O₅
• Molecular Weight: 392.495
• Mol file: 81806-30-6.mol

Synonyms:Boc-Phe-εAhx-OMe

Chemical Property of Boc-Phe-εAhx-OMe

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Boc-Phe-εAhx-OMe

There total 5 articles about Boc-Phe-εAhx-OMe which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

→ Boc-Phe-εAhx-OMe (81806-30-6)

Guidance literature:

With benzotriazol-1-ol; dicyclohexyl-carbodiimide; In tetrahydrofuran; for 0.5h; Cooling with ice;

With 4-methyl-morpholine; In tetrahydrofuran; at 20 ℃; for 13h; pH=9; Cooling with ice;

Reference yield: 85.0%

N-tert-butoxycarbonyl-L-phenylalanine (13734-34-4) + methyl 6-aminocaproate hydrochloride (1926-80-3) → Boc-Phe-εAhx-OMe (81806-30-6)

Guidance literature:

With TEA; benzotriazol-1-ol; dicyclohexyl-carbodiimide; In dichloromethane; 1.) 0 deg C, 2.) RT, overnight;

Reference yield: 82.0%

methanol (67-56-1) + C29H36N4O4 → Boc-Phe-εAhx-OMe (81806-30-6)

Guidance literature:

With nickel(II) bis(2,2,6,6-tetramethylheptane-3,5-dionate); at 100 ℃; for 12h; chemoselective reaction;

DOI:10.1021/acscatal.7b00442

upstream raw materials:

N-tert-butoxycarbonyl-L-phenylalanine

methyl 6-aminocaproate hydrochloride

6-(tert-butoxycarbonylamino)hexanoic acid

N-tert-butoxycarbonyl-6-aminohexanoic acid methyl ester

Downstream raw materials:

Boc-Gly-Phe-εAhx-OMe

6-[(S)-2-(2-Amino-acetylamino)-3-phenyl-propionylamino]-hexanoic acid methyl ester; hydrochloride

H-PrTyr-D-Met-Gly-Phe-εAhx-OH

H-iPrTyr-D-Met-Gly-Phe-εAhx-OH