81817-16-5

Upstream product

• 99768-32-8 7-chloro-3-phenyl-benzo[e][1,2,4]triazine-1-oxide 
• 100-47-0 benzonitrile 
• 613-92-3 N-hydroxyl-benzamidine 
• 1456-22-0 3-phenyl-4H-[1,2,4]oxadiazol-5-one 
• 90084-83-6 N-methyl-N-(m-chlorophenyl)hydrazine 
• 873-38-1 4-chloro-2-bromoaniline 
• 613-94-5 benzoic acid hydrazide 
• 63069-48-7 p-chloro-o-iodoaniline 
• 1966-16-1 5-chloro-2-nitrophenylhydrazine 
• 825-60-5 benzimidic acid ethyl ester 

Relevant academic research and scientific papers

Cobalt-Catalyzed, Directed Intermolecular C-H Bond Functionalization for Multiheteroatom Heterocycle Synthesis: The Case of Benzotriazine

Transition-metal-catalyzed, directed intermolecular C-H bond functionalization is synthetically useful but heavily underexplored in multiheteroatom heterocycle synthesis. Herein we report a cobalt catalytic method for the formation of a three-nitrogen-bearing benzotriazine scaffold via the coupling of arylhydrazine and oxadiazolone. This synthetic protocol features a low-cost base metal catalyst, a maximum number of heteroatoms built into a heterocycle, a distinct synthetic logic for benzotriazines, a superior step economy, and a broad substrate scope.

Palladium-Catalyzed ortho -Monoacylation of Arenes with Aldehydes via 1,2,4-Benzotriazine-Directed C-H Bond Activation

An efficient palladium-catalyzed C-H bond functionalization/ ortho -monoacylation reaction of 3-aryl-1,2,4-benzotriazines with (hetero)aryl or alkyl aldehydes has been developed, which offers a facile and alternative strategy for direct modification and further diversification of 3-aryl-1,2,4-benzotriazines. Bioactive 1,2,4-benzotriazine has been employed as a novel directing group for the palladium-catalyzed regioselective monoacylation of sp 2 C-H bond protocol with broad substrate scope and good functional group tolerance.

Copper-catalyzed domino reaction of 2-haloanilines with hydrazides: A new route for the synthesis of benzo[e][1,2,4]triazine derivatives

A copper-catalyzed domino reaction for the synthesis of benzo[e][1,2,4]triazine derivatives has been developed using readily available substituted 2-haloanilines and hydrazides as the starting materials. The procedure of the present method is mild, facile

Two-step syntheses of 3-methyl and 3-phenyl-1,2,4-benzotriazines

3-Methyl-1,2,4-benzotriazine and some of its derivatives were prepared in moderate yields (50-70%) via a reductive cyclization by a PtO 2-catalyzed hydrogenation of the corresponding 2- nitrophenylhydrazones of the pyruvic acid. The latter comp

A Novel Synthesis of 3-Aryl-1,2,4-benzotriazines via N-Phenylsulfonyl-N''-arylbenzamidrazones

3-Aryl-1,2,4-benzotriazines were obtained in good yields by the mercury(II) oxide-oxidation of N-phenylsulfonyl-N''-arylbenzamidrazones prepared from N-(phenylsulfonyl)benzohydrazonoyl chlorides and anilines.From the synthetic viewpoint for benzotriazines, this method may be of high utility on account of the availability of starting materials and higher yields.