81819-47-8Relevant academic research and scientific papers
A new route to homochiral piperidines
Jones,Turner,Howard
, p. 6329 - 6332 (1993)
The synthesis of an enantiomeric pair of enaminoesters from phenylglycine is described. Conjugate addition to α,β-enones, reductive cyclization-fragmentation to octahydroimidazopyridines and further reduction to remove the auxiliary atoms, completes a new route to homochiral piperidines in which the enaminoesters function as homochiral 'ethanal enamines'.
