155220-77-2

Upstream product

• 160000-37-3 (R)-2-amino-N-benzyl-2-phenylacetamide hydrochloride 
• 100-46-9 benzylamine 
• 81819-47-8 ((R)-Benzylcarbamoyl-phenyl-methyl)-carbamic acid benzyl ester 
• 17609-52-8 Z-D-phenylglycine 
• 875-74-1 (R)-phenylglycine 
• 147494-90-4 tert-butyl (R)-(2-(benzylamino)-2-oxo-1-phenylethyl)carbamate 
• 33125-05-2 Boc-D-Phg-OH 
• 144902-24-9 (R)-2-Amino-N-benzyl-2-phenyl-acetamide 

Downstream Products

• 175893-23-9 (3R,5R,7S,7aR)-1-benzyl-5,7-bis(tert-butoxycarbonyl)-3-phenylhexahydropyrrolo[1,2-a]imidazole 
• 175893-21-7 (3R,5R,7S,7aR)-1-benzyl-5-tert-butoxycarbonyl-7-methoxycarbonyl-7-methyl-3-phenylhexahydropyrrolo[1,2-a]imidazole 
• 175893-20-6 (3R,5R,7S,7aR)-dimethyl 1-benzyl-7-methyl-3-phenylhexahydro-1H-pyrrolo[1,2-a]imidazole-5,7-dicarboxylate 
• 175792-72-0 (R)-1-benzyl-4-phenyl-4,5-dihydroimidazole 

Relevant academic research and scientific papers

Methylene-bridged bis(imidazoline)-derived 2-oxopyrimidinium salts as catalysts for asymmetric Michael reactions

In nothing flat: The title salts, having planar nitrogen centers, were utilized successfully as phase-transfer catalysts for asymmetric Michael reactions of tert-butyl glycinate benzophenone Schiff base with vinyl ketone and chalcone derivatives, thus providing excellent levels of diastereo- and enantiocontrol (see scheme). Copyright

Synthesis of chiral C2-symmetric methylene- and boron-bridged bis(imidazolines)

A series of C2-symmetric boron-bridged bis(imidazolines) was obtained by lithiation of 2-imidazolines and subsequent reaction with dialkyl- or diarylhaloboranes. The corresponding 2-imidazolines were prepared by an efficient four-step sequence starting from N-tert-butoxycarbonyl-protected α-amino acids. C2-Symmetric methylenebis(imidazolines) were readily synthesized from chiral diamines by condensation with diethyl malonimidate. The bis(imidazolines) were used as ligands in the enantioselective cyclopropanation of styrene and allylic oxidation of cyclic alkenes. Georg Thieme Verlag Stuttgart.

A new route to homochiral piperidines

The synthesis of an enantiomeric pair of enaminoesters from phenylglycine is described. Conjugate addition to α,β-enones, reductive cyclization-fragmentation to octahydroimidazopyridines and further reduction to remove the auxiliary atoms, completes a new route to homochiral piperidines in which the enaminoesters function as homochiral 'ethanal enamines'.