81824-95-5Relevant academic research and scientific papers
Synthesis and antitubercular activity of pyridazinone derivatives
Husain, Asif,Ahmad, Aftab,Bhandari, Anil,Ram, Veerma
, p. 778 - 780 (2011)
Two series of pyridazinone derivatives (19-34) were synthesized and evaluated for antitubercular activities against Mycobacterium tuberculosis H37Rv strain. The results illustrated that among the synthesized compounds, compound 25, 5-(4-hydroxy-3-methoxybenzyl)-3-(4-chloro-phenyl)-1,6-dihydro-6-pyridazinone emerged as a lead compound with good antitubercular activity. Four more compounds, (21, 22, 29 & 33) were significant in their antitubercular action.
Synthesis and biological evaluation of some new pyridazinone derivatives
Husain, Asif,Drabu, Sushma,Kumar, Nitin,Alam, M. Mumtaz,Ahmad, Aftab
scheme or table, p. 742 - 748 (2012/04/04)
A series of pyridazinone derivatives (1934) were synthesized with an aim to synthesize safer anti-inflammatory agents. The compounds were evaluated for their anti-inflammatory, analgesic, ulcerogenic and lipid peroxidation (LPO) actions. The percentage inhibition in edema at different time intervals indicated that compounds 20, 26, 28 and 34 exhibited good anti-inflammatory potential, comparable with that of ibuprofen (85.77%) within a range of 67.4877.23%. The results illustrate that 5-(4-fluoro-benzyl)-3-(4-chloro-phenyl) -1,6-dihydro-6-pyridazinone (26) and 5-(4-chloro-benzyl)-3-(4-chloro-phenyl)-1, 6-dihydro-6-pyridazinone (20) showed best anti-inflammatory activity. Furthermore, activity is more in case of chloro substitution as compared with methyl-substitution. The compounds synthesized were also evaluated for their ulcerogenic and LPO action and showed superior gastrointestinal safety profile along with reduction in LPO as compared with that of the ibuprofen.
Stereospecific Palladium(II)-Catalyzed Cyclocarbonylation of 3-Aryl-1-propynes and Iodoarenes of Acid Chlorides To Form (E)-3-Arylidenebutenolides
Huang, Yujin,Alper, Howard
, p. 4534 - 4536 (2007/10/02)
Iodoarenes react with 3-aryl-1-propynes and carbon monoxide, in the presence of palladium acetate and triphenylphosphine, to form (E)-arylidenebutenolides in 33-88percent isolated yields.The same product is formed by substitution of acid chloride for a io
