Journal of the Chilean Chemical Society p. 778 - 780 (2011)
Update date:2022-08-04
Topics: Synthesis Antitubercular activity
Husain, Asif
Ahmad, Aftab
Bhandari, Anil
Ram, Veerma
Two series of pyridazinone derivatives (19-34) were synthesized and evaluated for antitubercular activities against Mycobacterium tuberculosis H37Rv strain. The results illustrated that among the synthesized compounds, compound 25, 5-(4-hydroxy-3-methoxybenzyl)-3-(4-chloro-phenyl)-1,6-dihydro-6-pyridazinone emerged as a lead compound with good antitubercular activity. Four more compounds, (21, 22, 29 & 33) were significant in their antitubercular action.
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