81917-06-8

Basic information

• Product Name: (AzidoMethyl)-cyclohexane
• Synonyms: (AzidoMethyl)-cyclohexane
• CAS NO: 81917-06-8
• Molecular Formula: C₇H₁₃N₃
• Molecular Weight: 139.19822
• Mol File: 81917-06-8.mol
• Article Data: 25

Chemical Properties

• Appearance: /
• CAS DataBase Reference: (AzidoMethyl)-cyclohexane(CAS DataBase Reference)
• NIST Chemistry Reference: (AzidoMethyl)-cyclohexane(81917-06-8)
• EPA Substance Registry System: (AzidoMethyl)-cyclohexane(81917-06-8)

Safety Data

• Hazardous Substances Data: 81917-06-8(Hazardous Substances Data)

Usage

Synthesis Reference(s)

The Journal of Organic Chemistry, 23, p. 1595, 1958 DOI: 10.1021/jo01105a001

Upstream product

• 286-08-8 bicyclo[4.1.0]heptane 
• 2550-36-9 Cyclohexylmethyl bromide 
• 14100-97-1 cyclohexylmethyl methanesulfonate 
• 98553-49-2 N-cyclohexylmethyl-N-nitroso-urea 
• 100-49-2 cyclohexylmethyl alcohol 
• 3725-11-9 cyclohexylmethyl p-toluenesulfonate 
• 98487-59-3 2-cyclohexylmethyl semicarbazide 

Downstream Products

• 1233082-90-0 C₂₀H₂₅N₃O₂ 
• 1233082-96-6 C₂₂H₂₇N₃O₂ 
• 1316650-33-5 C₁₆H₂₀N₄O₂ 
• 1316650-91-5 C₁₆H₂₁N₅O 
• 1316651-77-0 C₂₀H₂₃N₅OS 
• 1316651-21-4 C₂₂H₂₅N₅O 
• 1316651-48-5 C₂₂H₂₅N₅O 
• 1316649-83-8 C₁₀H₁₆N₄O₂ 
• 1403580-83-5 (E)-1-(1-benzyl-5-methyl-1H-1,2,3-triazol-4-yl)-3-(2,4-dichlorophenyl)prop-2-en-1-one 
• 1557968-81-6 4-(1-benzyl-5-methyl-1H-1,2,3-triazol-4-yl)-6-(2,4-dichlorophenyl)pyrimidin-2-amine 
• 133992-60-6 1-(1-benzyl-5-methyl-1H-1,2,3-triazol-4-yl)ethan-1-one 

Relevant articles and documents

Discovery and Characterization of 1 H-1,2,3-Triazole Derivatives as Novel Prostanoid EP4 Receptor Antagonists for Cancer Immunotherapy

The prostanoid EP4 receptor is one of the key receptors associated with inflammatory mediator PGE2-elicited immunosuppression in the tumor microenvironment. Blockade of EP4 signaling to enhance immunity-mediated tumor elimination has recently emerged as a promising strategy for cancer immunotherapy. In our efforts to discover novel subtype-selective EP4 antagonists, we designed and synthesized a class of 1H-1,2,3-triazole-based ligands that display low nanomolar antagonism activity toward the human EP4 receptor and excellent subtype selectivity. The most promising compound 59 exhibits single-digit nanomolar potency in the EP4 calcium flux and cAMP-response element reporter assays and effectively suppresses the expression of multiple immunosuppression-related genes in macrophage cells. On the basis of its favorable ADMET properties, compound 59 was chosen for further in vivo biological evaluation. Oral administration of compound 59 significantly inhibited tumor growth in the mouse CT26 colon carcinoma model accompanied by enhanced infiltration of cytotoxic T lymphocytes in the tumor tissue.

P-benzoquinone diazide core skeleton derivative as well as preparation method and application thereof

The invention relates to a p-benzoquinone diazide core skeleton derivative and a preparation method and application, thereof, belongs to. the field of organic chemistry, and can effectively treat-ovarian-ovarian cancer-carcinoma STAT3-ovarian, cancer-ATG4

1,2,3-Triazolium-Based Cationic Amphipathic Peptoid Oligomers Mimicking Antimicrobial Helical Peptides

Amphipathic cationic peptoids (N-substituted glycine oligomers) represent a promising class of antimicrobial peptide mimics. The aim of this study is to explore the potential of the triazolium group as a cationic moiety and helix inducer to develop potent antimicrobial helical peptoids. Herein we report the first solid-phase synthesis of peptoid oligomers incorporating 1,2,3-triazolium-type side chains and their evaluation against Escherichia coli, Enterococcus faecalis, and Staphylococcus aureus. Several triazolium-based oligomers, even of short length, selectively kill bacteria over mammalian cells. SEM visualization of S. aureus cells treated with a dodecamer and a hexamer reveals severe cell membrane damage and suggests that the longer oligomer acts by pore formation.