81917-14-8Relevant articles and documents
A Mild and Efficient Degradation of Ring A of Steroids
Boar, Robin B.,Jones, Susan L.,Patel, Arvind C.
, p. 513 - 516 (2007/10/02)
17-β-acetoxy-4,5-secoandrost-3-yn-5-one and 4,5-secopregn-3-yne-5,20-dione, readily available by Eschenmoser-Tanabe fragmentaton, have been rearranged to corresponding 2-ynes, which were cleaved to afford 2,5-seco-3,4-dinor-derivatives in excellent overall yield.The release of toluene-p-sulphinic acid during the fragmentation step can lead to the acetylation sulphinylation of an extraneous hydroxy-group.The active sulphinylating species is evidently p-tolyl toluene-p-sulphinyl sulphone.