81971-16-6

Upstream product

• 109-99-9 tetrahydrofuran 
• 2809-67-8 oct-2-yne 
• 67-66-3 chloroform 
• 104-53-0 3-phenyl-propionaldehyde 

Relevant academic research and scientific papers

Construction of chiral α-tert-amine scaffoldsviaamine-catalyzed asymmetric Mannich reactions of alkyl-substituted ketimines

Stereoselective Mannich reactions of aldehydes with ketimines provide chiral β-amino aldehydes that bear an α-tert-amine moiety. However, the structural variation of the ketimines is limited due to the formation of inseparableE/Zisomers, low reactivity, and other synthetic difficulties. In this study, a highly diastereodivergent synthesis of hitherto difficult-to-access β-amino aldehydes that bear a chiral α-tert-amine moiety was achieved using the amine-catalyzed Mannich reactions of aldehydes with less-activatedZ-ketimines that bear both alkyl and alkynyl groups.

An improved synthesis of dialkylcyclopropenones

Dialkylcyclopropenones are formed in high yields when alkynes are treated with chloroform-butyllithium in THF at - 78 °C followed by acidic hydrolysis of the dichlorocyclopropene intermediates at low temperatures.