81976-70-7Relevant articles and documents
Overcoming product inhibition in catalysis of the intramolecular Schmidt reaction
Motiwala, Hashim F.,Fehl, Charlie,Li, Sze-Wan,Hirt, Erin,Porubsky, Patrick,Aube, Jeffrey
supporting information, p. 9000 - 9009 (2013/07/26)
A method for carrying out the intramolecular Schmidt reaction of alkyl azides and ketones using a substoichiometric amount of catalyst is reported. Following extensive screening, the use of the strong hydrogen-bond-donating solvent hexafluoro-2-propanol was found to be consistent with low catalyst loadings, which ranged from 2.5 mol % for favorable substrates to 25 mol % for more difficult cases. Reaction optimization, broad substrate scope, and preliminary mechanistic studies of this improved version of the reaction are described.
Structure-based design of novel class II c-Met inhibitors: 1. Identification of pyrazolone-based derivatives
Norman, Mark H.,Liu, Longbin,Lee, Matthew,Xi, Ning,Fellows, Ingrid,D'Angelo, Noel D.,Dominguez, Celia,Rex, Karen,Bellon, Steven F.,Kim, Tae-Seong,Dussault, Isabelle
experimental part, p. 1858 - 1867 (2012/05/05)
Deregulation of c-Met receptor tyrosine kinase activity leads to tumorigenesis and metastasis in animal models. More importantly, the identification of activating mutations in c-Met, as well as MET gene amplification in human cancers, points to c-Met as a
Anticonvulsant and anxiolytic lactam and thiolactam derivatives
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, (2008/06/13)
This invention relates to lactam and thiolactam derivatives having useful anticonvulsant and anxiolytic activity, pharmaceutical compositions containing these compounds and therapeutic applications using such compositions.
