53101-33-0

Upstream product

• 872-50-4 1-methyl-pyrrolidin-2-one 
• 100-39-0 benzyl bromide 
• 1290070-22-2 C₁₄H₂₇NO₄ 
• 1290070-25-5 C₂₁H₃₃NO₄ 
• 1290070-28-8 C₁₇H₂₅NO₄ 
• 1290070-31-3 C₂₃H₂₉NO₄ 
• 1290070-50-6 C₂HF₃O₂*C₁₈H₂₁NO₂ 
• 74-83-9 methyl bromide 
• 81976-70-7 3-benzyl-2-pyrrolidinone 

Relevant academic research and scientific papers

Synthesis of quaternary α-perfluoroalkyl lactams via electrophilic perfluoroalkylation

Efficient protocols enabling the rapid installation of trifluoromethyl, as well as further functionalized fluoroalkyl groups by an electrophilic perfluoroalkylation of lactam-derived ketene silyl amides (KSAs) using hypervalent iodine reagents 1 and 2 have been developed.

Design, synthesis, and cyclization of 4-aminobutyric acid derivatives: Potential candidates as self-immolative spacers

Self-immolative spacers have gained significant interest in recent years due to their utility in numerous prodrug, sensor and drug delivery systems. However, there are a very limited number of spacers that are capable of undergoing spontaneous and rapid reactions under mild conditions. To address this need, 4-aminobutyric acid derivatives were explored as a potential class of self-immolative spacers. Using a modular approach, eleven N- and α-substituted derivatives of 4-aminobutyric acid were synthesized, and their intramolecular cyclizations to γ-lactams were studied. Kinetics experiments were carried out at physiological pH and temperature, and the observed half-lives for the spacers ranged from 2 to 39 s, depending on the molecular structure. In addition, the pH dependence of the cyclization rate was also explored and it was found that cyclization still occurred rapidly at mildly acidic pH. Therefore, this class of compounds exhibits promise for incorporation into a variety of self-immolative systems where rapid cyclization reactions are desired.

Anticonvulsant and anxiolytic lactam and thiolactam derivatives

This invention relates to lactam and thiolactam derivatives having useful anticonvulsant and anxiolytic activity, pharmaceutical compositions containing these compounds and therapeutic applications using such compositions.