82002-20-8

Basic information

• Product Name: (+/-)1-O-HEXADECYL-3-O-TRIPHENYLMETHYLGLYCEROL
• Synonyms: (+/-)1-O-HEXADECYL-3-O-TRIPHENYLMETHYLGLYCEROL
• CAS NO: 82002-20-8
• Molecular Formula: C₃₈H₅₄O₃
• Molecular Weight: 558.83
• Mol File: 82002-20-8.mol
• Article Data: 9

Chemical Properties

• Appearance: /
• CAS DataBase Reference: (+/-)1-O-HEXADECYL-3-O-TRIPHENYLMETHYLGLYCEROL(CAS DataBase Reference)
• NIST Chemistry Reference: (+/-)1-O-HEXADECYL-3-O-TRIPHENYLMETHYLGLYCEROL(82002-20-8)
• EPA Substance Registry System: (+/-)1-O-HEXADECYL-3-O-TRIPHENYLMETHYLGLYCEROL(82002-20-8)

Safety Data

• Hazardous Substances Data: 82002-20-8(Hazardous Substances Data)

Usage

General Description

(+/-)1-O-Hexadecyl-3-O-triphenylmethylglycerol is a chemical compound that belongs to the glycerol derivative group. It is a synthetic compound that is composed of a hexadecyl (16-carbon) chain attached to the first carbon on the glycerol backbone, along with a triphenylmethyl group attached to the third carbon. (+/-)1-O-HEXADECYL-3-O-TRIPHENYLMETHYLGLYCEROL is often used in the development of lipophilic molecules and in studying the activity of lipophilic compounds. It has also been studied for its potential applications in drug delivery systems and as a pharmaceutical agent. Additionally, it has been investigated for its potential biocompatibility and biodegradability in various medical and pharmaceutical applications.

Upstream product

• 6145-69-3 3-(hexadecyloxy)-1,2-propanediol 
• 76-83-5 trityl chloride 
• 89496-73-1 4-(n-hexadecyloxymethyl)-2,2-dimethyl-1,3-dioxolane 
• 112-82-3 hexadecanyl bromide 
• 6068-28-6 tosylate de n-hexadecyle 
• 36653-82-4 1-Hexadecanol 
• 117606-92-5 cetyl glycidyl ether 
• 18371-73-8 1-chloro-3-hexadecylhydroxy-2-propanol 

Downstream Products

• 6076-35-3 1,2-dihexadecylglycerol 
• 158268-05-4 1,2-Di-O-hexadecyl-3-O-tritylglycerol 
• 18678-94-9 2-benzyloxy-3-hexadecyloxy-1-propanol 
• 78119-19-4 2-hydroxy-3-(hexadecyloxy)-propyl 2-trimethylammonioethyl phosphate 
• 18678-98-3 Rac_. 1-O-Hexadecyl-2-O-benzylglycero-3-phosphocholin 
• 96924-84-4 Phosphorochloridic acid 2-benzyloxy-3-hexadecyloxy-propyl ester 2-bromo-ethyl ester 
• 86355-00-2 carbamyl-PAF 
• 82002-26-4 Acetic acid (2R,3S,4S,5R,6R)-3,5-diacetoxy-2-acetoxymethyl-6-(2-benzyloxy-3-hexadecyloxy-propoxy)-tetrahydro-pyran-4-yl ester 
• 873842-92-3 C₄₅H₆₆O₅ 
• 1263034-20-3 C₃₉H₅₆O₅S 
• 873842-80-9 1-hexadecyl-2-(5'-hexenyl)-3-tritylglycerol 
• 596-31-6 methoxytriphenylmethane 
• 6145-69-3 3-(hexadecyloxy)-1,2-propanediol 
• 142826-74-2 Phosphoric acid 2-benzyloxy-3-hexadecyloxy-propyl ester 2-bromo-ethyl ester 

Relevant articles and documents

Design, synthesis and cytotoxicity of chimeric erlotinib-alkylphospholipid hybrids

Two series of erlotinib-alkylphospholipid hybrids were prepared and evaluated for their antiproliferative activities against a panel of four cell lines representing lung, breast, liver and skin cancers using erlotinib and miltefosine as reference standards. Amide analogs elicited more enhanced cytotoxic activity than analogous esters. Amide derivatives 8d and 8e exhibited promising broad-spectrum antiproliferative activity and higher efficacy than reference erlotinib and miltefosine. Their cellular GI50 values was in the ranges of 24.7–46.9 μM and 26.8–43.1 μM for 8e and 8d respectively. Assay results of the inhibitory activity of the prepared compounds on EGFR kinase reaction and Akt phosphorylation in conjugation with statistical correlation analysis indicated that other mechanisms might contribute to their elicited cytotoxicities. In addition, statistical correlation analysis revealed that mechanisms of elicited cytotoxicities for amide series might be different from ester series. In addition, correlation analysis indicated variations in the mechanisms according to the types of cell line.

IMPROVED PROCESS FOR THE PREPARATION OF OXIDIZED PHOSPHOLIPIDS

Novel synthetic routes, which are highly applicable for industrial preparation of therapeutically beneficial oxidized phospholipids are disclosed. Particularly, novel methods for efficiently preparing compounds having a glycerolic backbone and one or more oxidized moieties attached to the glycerolic backbone, which are devoid of column chromatography are disclosed. Further disclosed are novel methods of introducing phosphorous-containing moieties such as phosphate moieties to compounds having glycerolic backbone and intermediates formed thereby.

Synthesis of 1-O-alkyl-2-acyl-glycerophosphocholine with branched fatty acid esters

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