820220-10-8Relevant academic research and scientific papers
Toward lead-oriented synthesis: One-pot version of castagnoli condensation with nonactivated alicyclic anhydrides
Ryabukhin, Sergey V.,Panov, Dmitriy M.,Granat, Dmitry S.,Ostapchuk, Eugeniy N.,Kryvoruchko, Dmitriy V.,Grygorenko, Oleksandr O.
supporting information, p. 146 - 153 (2014/04/03)
One-pot variation of Castagnoli condensation, that is, reaction of cyclic anhydrides, amines, and aldehydes, has been developed as a combinatorial approach to 1,2-disubstituted 5-oxopyrrolidine- and 6-oxopiperidine-3-carboxylic acids, as well as their benzo-analogues. Utility of the method to multigram preparation of building blocks and synthetic intermediates was also demonstrated. The final products are obtained in high yields and diastereoselectivity. The method fits well in the concept of lead-oriented synthesis; in particular, it can be used for the design of lead-like compound libraries, even if the strictest cut-offs are applied to the physicochemical properties of their members.
METHOD FOR PRODUCING ALCOHOL COMPOUND
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Page/Page column 9, (2012/01/15)
A method for producing an alcohol compound, wherein a carboxylic acid ester compound is reduced with hydrogen in the presence of a ruthenium complex which is obtained by reacting an imidazolium salt (A) having at least one optionally substituted amino group with a ruthenium compound (B) in the presence of a base (C).
Scalable methodologies for the synthesis of novel unsymmetrically substituted secondary amines
Roman, Gheorghe
experimental part, p. 131 - 140 (2012/06/18)
Fast, easy, and scalable methodologies for the synthesis of unsymmetrically substituted secondary amines containing naphthalene, indole, pyridine and imidazole moieties through reductive amination were explored. The investigated operating procedures were
