82073-54-9

Upstream product

• 5663-67-2 2-acetoxybenzaldehyde 
• 107-21-1 ethylene glycol 
• 7381-30-8 2,2,7,7-tetramethyl-3,6-dioxa-2,7-disilaoctane 
• 90-02-8 salicylaldehyde 

Downstream Products

• 82073-05-0 1-<α-(2-hydroxyethoxy)-2-acetyloxybenzyl>-5-fluorouracil 
• 99044-66-3 1,3-bis<α-(2-hydroxyethoxy)-2-acetoxybenzyl>-5-fluorouracil 
• 6398-87-4 3-aminobenzaldehyde ethylene acetal 
• 6988-19-8 2-(1,3-dioxolan-2-yl)phenol 

Relevant academic research and scientific papers

One-Pot Generation of Benzynes from Phenols: Formation of Primary Anilines by the Deoxyamination of Phenols

Benzynes were selectively generated in situ from phenols and trapped regioselectively with potassium hexamethyldisilazide to form primary anilines following acidic workup. The direct conversion of a phenolic hydroxyl group into a free amino group is a useful method for the preparation of primary aryl amines that are hard to synthesize by using coupling reactions involving phenol derivatives with ammonia. Whereas reactions of ortho- and meta-substituted phenols produced meta-substituted anilines exclusively, those of para-substituted phenols provided ortho-silylanilines.

Novel uracil derivatives, process for preparing the same and a pharmaceutical composition containing the same

Novel uracil derivatives of the formula STR1 (wherein R1, R2 R3 and X are defined in the description) and their pharmaceutically acceptable salts, process for preparing the same and pharmaceutical composition containing the same are disclosed. The uracil derivatives have good antitumor activity and, therefore, are useful as antitumor preparation.