82125-40-4Relevant academic research and scientific papers
Simple N,N-dimethyl phenylsulfonamides show potent anticonvulsant effect in two standard epilepsy models
Tanaka, Tomoyuki,Yajima, Nana,Kiyoshi, Tomoko,Miura, Yoshiki,Iwama, Seiji
, p. 94 - 97 (2016/12/09)
Optimization of the previously reported benzothiazine analogue A led to the identification of compound 1, which showed anti-convulsant activity in two golden standard animal models of seizure, the MES and scPTZ models. Structure-activity relationship investigation of compound 1 revealed compounds 2, 6 and 19 as attractive anti-epileptic drug (AED) candidates with potent anticonvulsant effect in both the MES and scPTZ models. As these compounds are structurally different from existing AEDs, determination of their mechanism of actions could provide clues to understanding current therapy-resistant seizures. Moreover, these simple phenylsulfoneamide compounds could be good starting points for searching broad spectrum AEDs by such in vivo screening.
CARBOXYLIC ACID COMPOUND
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Page/Page column 23, (2011/04/14)
To find a therapeutic agent and/or a preventive agent for diabetes mellitus or the like having excellent activity and safety. A compound represented by the following general formula (I), or a pharmacologically acceptable salt thereof. In the formula, X re
Conversion of sterically hindered phenols into the corresponding N,N-dimethylarenesulfonamides via the Newman-Kwart rearrangement
Wagenaar, Anno,Engberts, Jan B. F. N.
, p. 91 - 94 (2007/10/02)
The 2-alkyl- and 2,6-dialkylbenzenesulfonyl chlorides 5a-f were obtained in high yield by chlorination of the correspondingly substituted S-aryl N,N-dialkylthiocarbamates 4a-g.These precursors have been synthesized via the Newman-Kwart rearrangement of th
