82127-26-2

Usage

Uses

Used in Pharmaceutical Industry:
2-Bromo-4,6-diphenylnicotinonitrile is used as a key intermediate in the synthesis of various pharmaceutical agents. Its unique structure and reactivity allow for the development of complex molecules with potential therapeutic effects, contributing to the advancement of new drug formulations.
Used in Agrochemical Industry:
In the agrochemical sector, 2-Bromo-4,6-diphenylnicotinonitrile is utilized as a precursor in the production of pesticides. Its chemical properties enable the creation of bioactive molecules that can effectively control pests and diseases in agriculture, thereby enhancing crop protection and productivity.
Used in Organic Synthesis:
2-Bromo-4,6-diphenylnicotinonitrile is employed as a valuable building block in organic synthesis. Its versatile reactivity and structural features make it an essential component in the creation of more complex chemical structures with potential applications in various fields, including materials science, chemical research, and the development of novel compounds with specific properties.
Used in Research and Development:
2-Bromo-4,6-diphenylnicotinonitrile is also used as a valuable tool in the research and development of new drugs and agricultural products. Its unique structural features and reactivity provide a foundation for exploring and understanding the properties of new chemical entities, ultimately contributing to the discovery of innovative and effective solutions in healthcare and agriculture.

Upstream product

• 78564-24-6 2,2'-bis(3-cyano-4,6-diphenylpyridyl) disulfide 
• 82447-81-2 2-bromo-3-carbamoyl-4,6-diphenylpyridine 
• 82447-83-4 2-carbamoyl-4,6-diphenylpyridine-2-thione 
• 82447-76-5 3-oxo-2,3-dihydro-4,6-diphenylisothiazolo<5,4-b>pyridine 
• 58327-74-5 4,6-diphenyl-2-thioxo-1,2-dihydropyridine-3-carbonitrile 
• 94360-09-5 3-benzoyl-1-bromo-2-phenyl-1,1-dicyanopropane 
• 60847-68-9 4,6-diphenyl-2-methoxypyridine-3-carbonitrile 
• 62940-90-3 2-(3-oxo-1,3-diphenylpropyl)malononitrile 

Downstream Products

• 60847-68-9 4,6-diphenyl-2-methoxypyridine-3-carbonitrile 
• 1179487-80-9 3-cyano-4,6-diphenyl-2-fluoropyridine 
• 16232-42-1 2-oxo-4,6-diphenyl-1,2-dihydropyridine-3-carbonitrile 
• 78564-24-6 2,2'-bis(3-cyano-4,6-diphenylpyridyl) disulfide 
• 78564-31-5 2-Ethylsulfanyl-4,6-diphenyl-nicotinonitrile 
• 82447-82-3 2-piperidylmercapto-3-cyano-4,6-diphenylpyridine 
• 78564-36-0 3-Amino-6-(4-methoxy-phenyl)-4-phenyl-thieno[2,3-b]pyridine-2-carbonitrile 
• 78564-30-4 methyl-2-(4,6-diphenyl-3-cyanopyridin-2-yl) acetate 
• 78564-38-2 3-Amino-4,6-diphenyl-thieno<2,3-b>pyridin-2-carbonsaeuremethylester 
• 78564-27-9 2-Cyanomethylsulfanyl-4,6-diphenyl-nicotinonitrile 
• 78564-41-7 2-ethylmercapto-3-carbamoyl-4,6-diphenylpyridine 
• 82458-43-3 3-bromo-4,6-diphenylisothiazolo<5,4-b>pyridine 
• 82447-83-4 2-carbamoyl-4,6-diphenylpyridine-2-thione 
• 82447-76-5 3-oxo-2,3-dihydro-4,6-diphenylisothiazolo<5,4-b>pyridine 

Relevant academic research and scientific papers

Synthesis of 2-Cyanamino-4,6-diphenylpyridine-3-carbonitrile

The nucleophilic displacement of bromo, alkylthio and alkylsulphonyl groups from pyridine systems by cyanamide is studied in order to obtain a previously unreported 2-cyanaminopyridine-3-carbonitrile.A one-step synthesis of the same compound by cyclization in basic medium of the non-isolated Michael adduct of (E)-1,3-diphenylpropenone and propanedinitrile is also described.

CYCLIZATION OF NITRILES. IX. SYNTHESES BASED ON 2-ARYL-3-AROYL-1,1-DICYANOPROPANES

2-Aryl-3-aroyl-1,1-dicyanopropanes and 2-aryl-3-aroyl-1-bromo-1,1-dicyanopropanes were synthesized from chalcones and malononitrile and were converted into 4,6-diaryl-2-bromo-3-cyanopyridines and 3-cyano-2(1H)-pyridinethiones.The 2-aryl-3-aroyl-1-bromo-1,1-dicyanopropanes proved convenient intermediates for the production of the corresponding cyclopropanes and other compounds.By their reaction with urea a new method was developed for the production of substituted 3-cyano-2(1H)-pyridinethiones.The 2-bromo-3-cyanopyridines contain a mobile bromine atom readily exchanged for the various nucleophilic residues of alcohols and amines and for iodide, and cyano and thiocyanato groups.The 3-cyano-2(1H)-pyridinethiones were used in the synthesis of 3-aminothienopyridines through the isolated 2-Z-methylthio-3-cyanopyridines.

SYNTHESIS OF 3-OXOISOTHIAZOLOPYRIDINES

3-Oxoisothiazolopyridines were synthesized for the first time by the reaction of 3-cyanopyridine-2-thiones or bis(3-cyanopyridyl) disulfides with concentrated sulfuric acid.It is demonstrated that 3-carbamoylpyridine-2-thiones are formed as intermediates.The 3-oxoisothiazolopyridines were converted to 3-bromoisothiazolopyridines and pyridine-2-thiones.The bromination of pyridine-2-thione was studied.

CYCLIZATION REACTIONS OF NITRILES. 2-ARYL-3-(2-THENOYL)-1,1-DICYANOPROPANES AND PYRIDINE DERIVATIVES BASED ON THEM

In the reaction of 1,1,1-trifluoro-3-(2-thenoyl)acetone with arylidenemalononitriles acid cleavage of the products from Michael addition takes place with the formation of 2-aryl-3-(2-thenoyl)-1,1-dicyanopropanes.They were used for the synthesis of 4-aryl-2-bromo-6-(2-thienyl)-3-cyanopyridines and 4-aryl-6-(2-thienyl)-3-cyano-2(1H)-pyridinethiones and condensed heterocyclic compounds based on them.