94360-49-3Relevant academic research and scientific papers
Wang-OSO3H catalyzed green synthesis of 2-arylamino-3-cyanopyridine derivatives under ultrasound: Their assessment as potential inhibitors of SIRT1
Challa, Chandra Sekhar,Kapavarapu, Ravikumar,Katari, Naresh Kumar,Nallanchakravarthula, Varadacharyulu,Nayakanti, Devanna,Pal, Manojit
, (2022/01/26)
New approaches / strategies to develop potential anticancer agents are necessary not only to address the increasing incidences of cancer worldwide but also to overcome the multifaceted problem of drug resistance. SIRT1, the most widely studied among all t
FeF3-catalyzed MCR in PEG-400: Ultrasound assisted synthesis of: N -substituted 2-aminopyridines
Kumar Reddy, Dinne Naresh,Chandrasekhar, Kothapalli Bannoth,Siva Ganesh, Yaddanapudi Sesha,Reddy, G. Rajeshwar,Kumar, J. Pradeep,Kapavarapu, Ravi Kumar,Pal, Manojit
, p. 67212 - 67217 (2016/08/02)
FeF3 catalyzed four component reaction under ultrasound irradiation was explored for the first time to prepare N-substituted 2-aminopyridines in good yields. The methodology involved the use of readily available starting materials and PEG-400 u
Expedient N-arylation for the synthesis of 2-arylamino-3-cyanopyridines using ionic copper(I) complex as a catalyst
Zhang, Min,Xiong, Biao,Wang, Ting,Wang, Xiaoting,Yan, Fengxia,Ding, Yuqiang
experimental part, p. 1393 - 1404 (2012/08/07)
The N-arylation of 2-amino-3-cyanopyridines is firstly described by using ionic copper(I) complex (Phen)2Cu+BF4 - (phen = 1,10-phenanthroline) as an efficient catalyst. The synthetic protocol can be applied to synthesize a wide range of 2-arylamino-3-cyanopyridine products in good to excellent isolated yields. The resulted products are potentially building blocks for further preparation of biologically interesting products or useful ligands for metal catalysis.
CYCLIZATION OF NITRILES. IX. SYNTHESES BASED ON 2-ARYL-3-AROYL-1,1-DICYANOPROPANES
Shestopalov, A. M.,Promonenkov, V. K.,Sharanin, Yu. A.,Rodinovskaya, L. A.,Sharanin, S. Yu.
, p. 1382 - 1401 (2007/10/02)
2-Aryl-3-aroyl-1,1-dicyanopropanes and 2-aryl-3-aroyl-1-bromo-1,1-dicyanopropanes were synthesized from chalcones and malononitrile and were converted into 4,6-diaryl-2-bromo-3-cyanopyridines and 3-cyano-2(1H)-pyridinethiones.The 2-aryl-3-aroyl-1-bromo-1,1-dicyanopropanes proved convenient intermediates for the production of the corresponding cyclopropanes and other compounds.By their reaction with urea a new method was developed for the production of substituted 3-cyano-2(1H)-pyridinethiones.The 2-bromo-3-cyanopyridines contain a mobile bromine atom readily exchanged for the various nucleophilic residues of alcohols and amines and for iodide, and cyano and thiocyanato groups.The 3-cyano-2(1H)-pyridinethiones were used in the synthesis of 3-aminothienopyridines through the isolated 2-Z-methylthio-3-cyanopyridines.
